BD750 inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation. Treatment with BD750 induced tolDC that inhibited pro-inflammatory T cell immunity in vitro and in vivo.
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BD750, a potent immunosuppressant and JAK3/STAT5 inhibitor, suppresses IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM in mouse T cells and 1.1 μM in human T cells[1][2].
体内研究
BD750 can promote the generation of tolerogenic dendritic cells (tolDC) and enhance their functionality in experimental autoimmune encephalitis (EAE) in mice[2].
体外研究
BD750 inhibits human T cell proliferation, whether stimulated by anti-CD3/anti-CD28 mAbs or alloantigen, in a dose-dependent manner, with IC50 values of 1.1 ± 0.2 μM and 1.3 ± 0.2 μM, respectively[1].
BD750 also suppresses mouse T cell proliferation induced by ConA, PMA/ionomycin, or alloantigens, as well as human T cell proliferation triggered by PHA or PMA/ionomycin[1].
BD750 (5 or 20 μM) suppresses LPS-induced JAK-STAT5 signaling in dendritic cells (DC)[2].
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