产品说明书

BD750

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Chemical Structure| 892686-59-8 同义名 : -
CAS号 : 892686-59-8
货号 : A1327318
分子式 : C14H13N3OS
纯度 : 99%+
分子量 : 271.337
MDL号 : MFCD08132253
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(442.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BD750, a potent immunosuppressant and JAK3/STAT5 inhibitor, suppresses IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM in mouse T cells and 1.1 μM in human T cells[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.69mL

0.74mL

0.37mL

18.43mL

3.69mL

1.84mL

36.85mL

7.37mL

3.69mL
参考文献

[1]Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43.

[2]Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.