鸦胆子苦醇 /(+)-Brusatol
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货号：A132366
同义名：
NSC 172924;Brusatol
(+)-Brusatol 是一种天然来源的抗氧化剂 ，对 Nrf2 具有高亲和力，IC50 值为 0.2 μM。(+)-Brusatol 具有抗氧化、抗炎 和抗肿瘤 作用，可用于氧化应激相关疾病和癌症的研究。
(+)-Brusatol 化学结构
(+)-Brusatol 3D分子结构
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(+)-Brusatol 纯度/质量文件 产品仅供科研
货号：A132366
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(+)-Brusatol 质控信息
(+)-Brusatol 生物活性
描述
Brusatol is a type of quassinoid obtained from Brucea javanica, an evergreen shrub grown in Southeast Asia. i>in vitro, under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1α degradation and cancer cell death in a dose-dependent manner[3] [4] [5]
(+)-Brusatol 参考文献
[1] Vartanian S, Ma TP, et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics. 2016 Apr;15(4):1220-31.
[2] Willingham W Jr, Stafford EA, et al. Mechanism of eukaryotic protein synthesis inhibition by brusatol. Biochim Biophys Acta. 1981 Jul 27;654(2):169-74.
[3] Oh ET, Kim CW, Kim HG, Lee JS, Park HJ. Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia. Theranostics. 2017;7(14):3415-3431. Published 2017 Aug 11.
[4] Xiang Y, Ye W, Huang C, et al. Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway. Oxid Med Cell Longev. 2018;2018:2360427. Published 2018 Apr 18.
[5] Ma R, Li H, Zhang Y, et al. The toxic effects and possible mechanisms of Brusatol on mouse oocytes. PLoS One. 2017;12(5):e0177844. Published 2017 May 18.
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(+)-Brusatol 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.92mL
0.38mL
0.19mL
9.61mL
1.92mL
0.96mL
19.21mL
3.84mL
1.92mL
(+)-Brusatol 技术信息
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