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(+)-Brusatol

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Chemical Structure| 14907-98-3 同义名 : NSC 172924;Brusatol
CAS号 : 14907-98-3
货号 : A132366
分子式 : C26H32O11
纯度 : 99%+
分子量 : 520.526
MDL号 : MFCD01746220
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(48.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Brusatol is a type of quassinoid obtained from Brucea javanica, an evergreen shrub grown in Southeast Asia. i>in vitro, under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1α degradation and cancer cell death in a dose-dependent manner[3]. 0.5 μM brusatol significantly increased ROS accumulation after 24 h of treatment in pancreatic cancer cells[4]. Brusatol treatment led to the pronounced loss of Nrf2 in mouse oocytes, which lead to oocyte maturation failure and spindle/chromosomal defects[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.61mL

1.92mL

0.96mL

19.21mL

3.84mL

1.92mL
参考文献

[1]Vartanian S, Ma TP, et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics. 2016 Apr;15(4):1220-31.

[2]Willingham W Jr, Stafford EA, et al. Mechanism of eukaryotic protein synthesis inhibition by brusatol. Biochim Biophys Acta. 1981 Jul 27;654(2):169-74.

[3]Oh ET, Kim CW, Kim HG, Lee JS, Park HJ. Brusatol-Mediated Inhibition of c-Myc Increases HIF-1α Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia. Theranostics. 2017;7(14):3415-3431. Published 2017 Aug 11.

[4]Xiang Y, Ye W, Huang C, et al. Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway. Oxid Med Cell Longev. 2018;2018:2360427. Published 2018 Apr 18.

[5]Ma R, Li H, Zhang Y, et al. The toxic effects and possible mechanisms of Brusatol on mouse oocytes. PLoS One. 2017;12(5):e0177844. Published 2017 May 18.