规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamate ammonium | ✔ | 98% | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
99%+ | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | 99%+ | |||||||||||||||||
Sodium Salicylate | ✔ | 99%+ | |||||||||||||||||
Parthenolide | ✔ | p53 | 97% HPLC | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
98% | |||||||||||||||||
Phenethyl caffeate | ✔ | 99%+ | |||||||||||||||||
Andrographolide | ✔ | 99%+ | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | 98% | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
99%+ | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | NIK SMI1 is a potent, selective NIK inhibitor that inhibits NIK-catalysed hydrolysis of ATP to ADP with an IC50 value of 0.23±0.17 nM. NIK SMI1 inhibits the expression of the firefly luciferase reporter gene, which is regulated by NIK SMI1-responsive elements, in HEK293 cells with an IC50 value of 34±6 nM. In line with the expectation that the inhibition of NIK NIK SMI1 inhibited nuclear translocation of p52(RelB) (IC50=70 nM). Consistent with the expectation of NIK inhibition, NIK SMI1 inhibited BAFF-induced B-cell (mouse) survival in vitro with an IC50 of 373±64 nM[1]. |
Animal study | Pharmacological studies of NIK SMI1 in SD rats, CD-1 mice, beagles and cynomologous monkeys were 20, 32, 18 and 7.8 mL/kg per minute, respectively. The volume of distribution (Vd, litres/kg) was 1.35, 1.58, 0.778 and 1.39, respectively[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.74mL 0.55mL 0.27mL |
13.68mL 2.74mL 1.37mL |
27.37mL 5.47mL 2.74mL |
CAS号 | 1660114-31-7 |
分子式 | C20H19N3O4 |
分子量 | 365.383 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 120 mg/mL(328.42 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |