Clemastine fumarate is a selective antagonist of histamine H1 receptor with IC50 of 3 nM.

Bepotastine besilate is a selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

Desloratadine is an antagonist of histamine H1 receptor that is used to treat allergies.

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Chlorpheniramine maleate is an antagonist of histamine H1 receptor with IC50 of 12 nM.

Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM.

Tripelennamine HCl is an antagonist of H1-receptor that used as a psychoactive drug with antipruritic activity.

Hydroxyzine 2HCl is an antagonist of histamine H1-receptor that inhibits the binding of [3H]pyrilamine and [3H]desloratadine to histamine H1 receptor with IC50s of 10 nM and 19 nM.

Rupatadine fumarate is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.

Bilastine selectively antagonizes histamine H1 receptor and it is used to treat allergic rhinoconjunctivitis and urticaria.

Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines.

Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive.

Ebastine is a selective H1-histamine receptor antagonist.

Ketotifen fumarate is a noncompetitive H1 receptor antagonist and mast cell stabilizer that is used to treat asthma.

Brompheniramine maleate is an antagonist of histamine H1 receptors.

Carbinoxamine maleate is a blocker of histamine-H1 receptor with antihistamine and anticholinergic effects.

Doxylamine Succinate Salt is an antihistamine which inhibits histamine H1 receptors. It can be used as a short-term sedative and anticholinergic agent.

Cyclizine, a piperazine derivative, is an antihistaminic antiemetic that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness.

Pemirolast potassium is an antagonist of histamine H1 and mast cell stabilizer with antiallergic effect.

Loratadine is an inverse agonist of peripheral histamine H1-receptor with IC50 of > 32 μM.