Pemetrexed disodium heptahydrate是一种新型抗叶酸剂，其五聚谷氨酸形式对胸苷酸合成酶（TS）的Ki值为1.3 nM，对二氢叶酸还原酶（DHFR）为7.2 nM，对甘氨酰胺核糖核苷酸甲酰基转移酶（GARFT）为65 nM。

Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.

Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.

Levoleucovorin Calcium 具有抗肿瘤作用，也是 5-Fluorouracil 抗癌细胞毒性的增强剂。

Levomefolate Calcium is an artificial form of folate.

Pemetrexed disodium hemipenta hydrate是一种新型抗叶酸剂，其五聚谷氨酸形式对胸苷酸合成酶（TS）、二氢叶酸还原酶（DHFR）和甘氨酰胺核糖核苷酸甲酰基转移酶（GARFT）的Ki值分别为1.3 nM、7.2 nM和65 nM。

Levomefolic acid（5-MTHF）是一种天然存在的活性叶酸形式，具有口服活性，可以穿过血脑屏障。它是最常用的叶酸膳食补充剂。

Pemetrexed disodium (LY231514 disodium) 是一种抗叶酸类药物，其五聚谷氨酸形式能抑制胸苷酸合成酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)，Ki 值分别为 1.3、7.2 和 65 nM。

Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.

Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent.

Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.

Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.

DHFR-IN-4是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂，IC₅₀ 为 123 nM。该化合物还对 EGFR 和 HER2 有抑制活性，IC₅₀ 分别为 246 nM 和 357 nM，表现出广谱的抗癌活性，适用于癌症治疗的研究。

Aditoprime (Aditoprim) 是一种选择性细菌二氢叶酸还原酶 (DHFR) 抑制剂，抑制二氢叶酸向四氢叶酸的转化。对大肠杆菌和酪酸乳杆菌 DHFR 的 IC50 值分别为 47 nM 和 520 nM，表现出广谱抗菌活性和良好的药代动力学。

Pemetrexed(LY231514) 是一种抗叶酸剂，其对胸苷酸合成酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT) 的 Ki 值分别为 1.3 nM、7.2 nM 和 65 nM。

Leucovorin calcium is a reduced form of folic acid.

Methotrexate hydrate通过抑制细胞的 DNA 合成过程来影响细胞的生长和分裂，通常用于治疗癌症和某些自身免疫性疾病。

1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit dihydrofolate reductase (DHFR).

Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity.