Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR). Based on susceptibility levels, 73 and 68 of 96 fresh clinical isolates were susceptible to pyrimethamine (mean IC50 15.4 nM) and cycloguanil (mean IC50 11.1 nM), respectively. A highly significant positive correlation was found between pyrimethamine and cycloguanil, indicating in vitro cross-resistance between these antifolates[3]. Additionally, pyrimethamine failed to repress levels of SOD1 protein in HeLa cells or homogenates of liver, spinal cord and brain of wild-type mice[4]. The combinations of fluconazole plus sulfadiazine and pyrimethamine or fluconazole plus pyrimethamine were remarkably effective against T. gondii in vivo[5]. Sulfadoxine/pyrimethamine is well tolerated as treatment and when used as intermittent preventive treatment in pregnant African women[6].
Burkina Faso
... 展开 >> Université de Ouagadougou
Ouagadougou, Burkina Faso
Gambia
Medical Research Council Laboratories
Basse, Gambia
Ghana
Navrongo Health Research Centre
Navrongo, Ghana
Mali
Medical Research and Training Centre
Bamako, Mali 收起 <<
Burkina Faso
... 展开 >> Université de Ouagadougou
Ouagadougou, Burkina Faso
Gambia
Medical Research Council Laboratories
Basse, Gambia
Ghana
Navrongo Health Research Centre
Navrongo, Ghana
Mali
Medical Research and Training Centre
Bamako, Mali 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Not Applicable
Completed
-
United States, California
... 展开 >>
Los Angeles County - USC Med Ctr
Los Angeles, California, United States, 90033
Infectious Disease Med Group
Oakland, California, United States, 94609
San Francisco Gen Hosp
San Francisco, California, United States, 941102859
UCSF - San Francisco Gen Hosp
San Francisco, California, United States, 94110
Davies Med Ctr
San Francisco, California, United States, 94114
United States, District of Columbia
Georgetown Univ Med Ctr
Washington, District of Columbia, United States, 20007
United States, Georgia
Infectious Disease Research Consortium of Georgia
Atlanta, Georgia, United States, 30345
United States, Maryland
Johns Hopkins Hosp
Baltimore, Maryland, United States, 21205
United States, New York
Beth Israel Med Ctr
New York, New York, United States, 10003
Saint Vincent's Hosp and Med Ctr
New York, New York, United States, 10011
Harlem Hosp Ctr
New York, New York, United States, 10037
SUNY / Health Sciences Ctr at Stony Brook
Stony Brook, New York, United States, 117948153
United States, North Carolina
Duke Univ Med Ctr
Durham, North Carolina, United States, 27710
United States, Oregon
Portland Veterans Adm Med Ctr / Rsch & Education Grp
Portland, Oregon, United States, 97210
United States, Tennessee
Regional Med Ctr at Memphis
Memphis, Tennessee, United States, 38103
United States, Texas
Gathe, Joseph, M.D.
Houston, Texas, United States, 77004
Baylor College of Medicine
Houston, Texas, United States, 77030
United States, Virginia
Infectious Disease Physicians Inc
Annandale, Virginia, United States, 22203
Canada, Alberta
Southern Alberta HIV Clinic / Foothills Hosp
Calgary, Alberta, Canada
Canada, British Columbia
Dr Julio S G Montaner
Vancouver, British Columbia, Canada
Canada, Ontario
Wellesley Hosp
Toronto, Ontario, Canada
Canada, Quebec
Dr Emil Toma / Hotel Dieu de Montreal
Montreal, Quebec, Canada 收起 <<
Pregnancy
Mal... 展开 >>aria in Pregnancy
Malaria 收起 <<
Phase 3
Not yet recruiting
October 2019
Kenya
... 展开 >> Ahero Sud-countyHospital
Not yet recruiting
Ahero, Kisumu, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Homa Bay County Hospital
Not yet recruiting
Homa Bay, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Rabour Sub-county Hospital
Not yet recruiting
Kisumu, Kenya
Contact: Simon Kariuki, PhD + 254725389246 SKariuki@kemricdc.org
Malawi
Chikwawa District Hospital
Not yet recruiting
Chikwawa, Malawi
Contact: Victor Mwapasa, PhD +265999981496 vmwapasa@gmail.com
Mangochi District Hospital
Not yet recruiting
Mangochi, Malawi
Contact: Kenneth Maleta, PhD +265888232202 ken.maleta@gmail.com
Tanzania
Handeni District Hospital
Handeni, Tanzania
Korogwe District Hospital
Korogwe, Tanzania 收起 <<
Mozambique
... 展开 >> Bela Vista Clinic
Bela Vista, Matutuine, Mozambique
Namaacha Clinic
Namaacha, Mozambique
South Africa
Ndumo Clinic
Ndumo, KwaZulu Natal, South Africa
Lulekani Clinic
Lulekani, Limpopo, South Africa
Naas Clinic
Naas, Mpumalanga, South Africa
Swaziland
Ndzevane Clinic
Ndzevane, Swaziland
Vuvulane Clinic
Vuvulane, Swaziland 收起 <<
Tanzania
... 展开 >> Kibaoni Health Centre
Ifakara, Kilombero District, Tanzania
St Francis Designated District Hospital
Ifakara, Kilombero District, Tanzania 收起 <<
Malaria in Pregnancy
... 展开 >> HIV Infection 收起 <<
Phase 3
Unknown
-
Central African Republic
... 展开 >>
Maternité de l'Hôpital communautaire
Not yet recruiting
Bangui, Central African Republic
Maternité de l'Hôpital de l'Amitié
Not yet recruiting
Bangui, Central African Republic
Maternité de la Gendarmerie Nationale
Not yet recruiting
Bangui, Central African Republic
Maternité du centre de santé des Castors
Not yet recruiting
Bangui, Central African Republic 收起 <<
Nigeria
... 展开 >> Damboa Hospital Borno state and Park Lane hospital Enugu state
Recruiting
Enugu,, borno State and Enugu state, Nigeria
Contact: Elvis N Shu Cell: + 234 803 317 0257 shuneba@gmail.com
Principal Investigator: Elvis Shu 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Not Applicable
Completed
-
United States, California
... 展开 >>
USC CRS
Los Angeles, California, United States, 90033
Stanford CRS
Palo Alto, California, United States, 94304
Ucsd, Avrc Crs
San Diego, California, United States, 92103
United States, Florida
Univ. of Miami AIDS CRS
Miami, Florida, United States, 33136
United States, Maryland
Johns Hopkins Adult AIDS CRS
Baltimore, Maryland, United States, 21287
United States, Missouri
Washington U CRS
St. Louis, Missouri, United States
United States, New York
SUNY - Buffalo, Erie County Medical Ctr.
Buffalo, New York, United States, 14215
NY Univ. HIV/AIDS CRS
New York, New York, United States, 10016
Cornell University A2201
New York, New York, United States, 10021
Memorial Sloan-Kettering Cancer Ctr.
New York, New York, United States, 10021
United States, North Carolina
Unc Aids Crs
Chapel Hill, North Carolina, United States, 27599
Duke Univ. Med. Ctr. Adult CRS
Durham, North Carolina, United States, 27710
United States, Pennsylvania
Pitt CRS
Pittsburgh, Pennsylvania, United States, 15213 收起 <<
Tanzania
... 展开 >> National Institute for Medical Research
Not yet recruiting
Tanga, Tanzania, 255
Contact: Centre Director +255272646084 tanga@nimr.or.tz
Contact: Vito Baraka, PhD +255715380010 vitobaraka@gmail.com
Principal Investigator: Geofrey Makenga, MD, MSc
Sub-Investigator: Vito Baraka, PhD
Sub-Investigator: Filbert Fransis, MSc
Sub-Investigator: Rashid Madebe, MSc
Sub-Investigator: Edwin Liheluka, MSc 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Phase 1
Completed
-
United States, California
... 展开 >>
Los Angeles County - USC Med Ctr
Los Angeles, California, United States, 90033
United States, Florida
Univ of Miami School of Medicine
Miami, Florida, United States, 331361013
United States, Massachusetts
Univ of Massachusetts Med Ctr
Worcester, Massachusetts, United States, 01655
United States, New York
Bronx Municipal Hosp Ctr/Jacobi Med Ctr
Bronx, New York, United States, 10461
Montefiore Med Ctr / Bronx Municipal Hosp
Bronx, New York, United States, 10467
Bronx Veterans Administration / Mount Sinai Hosp
Bronx, New York, United States, 10468
Nassau County Med Ctr
East Meadow, New York, United States, 11554
Bellevue Hosp / New York Univ Med Ctr
New York, New York, United States, 10016
Cornell Univ Med Ctr
New York, New York, United States, 10021
SUNY - Stony Brook
Stony Brook, New York, United States, 117948153
United States, South Carolina
Julio Arroyo
West Columbia, South Carolina, United States, 29169 收起 <<
India
... 展开 >> Pfizer Investigational Site
Dispur Guwahati, Assam, India, 781006
Pfizer Investigational Site
Bambolim, Gao, India, 403002
Pfizer Investigational Site
Nagpur, Maharashtra, India, 440 018
Pfizer Investigational Site
Parel Mumbai, Maharashtra, India, 400012
Pfizer Investigational Site
Rourkela, Orissa, India, 769005
Pfizer Investigational Site
Vellore, Tamil Nadu, India, 632 004
Pfizer Investigational Site
Indore, India, 452001 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Phase 1
Completed
-
United States, New York
... 展开 >>
Memorial Sloan-Kettering Cancer Ctr.
New York, New York, United States, 10021
United States, North Carolina
Unc Aids Crs
Chapel Hill, North Carolina, United States, 27599 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Phase 2
Completed
-
United States, California
... 展开 >>
USC CRS
Los Angeles, California, United States, 900331079
United States, Florida
Univ. of Miami AIDS CRS
Miami, Florida, United States, 331361013
United States, Hawaii
Queens Med. Ctr.
Honolulu, Hawaii, United States, 96816
Univ. of Hawaii at Manoa, Leahi Hosp.
Honolulu, Hawaii, United States, 96816
United States, Illinois
Northwestern University CRS
Chicago, Illinois, United States, 60611
Cook County Hosp. CORE Ctr.
Chicago, Illinois, United States, 60612
United States, Indiana
Indiana Univ. School of Medicine, Infectious Disease Research Clinic
Indianapolis, Indiana, United States, 462025250
Methodist Hosp. of Indiana
Indianapolis, Indiana, United States, 46202
United States, Maryland
Johns Hopkins Adult AIDS CRS
Baltimore, Maryland, United States, 21287
United States, Missouri
Washington U CRS
St. Louis, Missouri, United States, 63110
St. Louis ConnectCare, Infectious Diseases Clinic
St. Louis, Missouri, United States
United States, New York
SUNY - Buffalo, Erie County Medical Ctr.
Buffalo, New York, United States, 13210
Beth Israel Med. Ctr. (Mt. Sinai)
New York, New York, United States, 10003
NY Univ. HIV/AIDS CRS
New York, New York, United States
United States, Ohio
Univ. of Cincinnati CRS
Cincinnati, Ohio, United States, 452670405
The Ohio State Univ. AIDS CRS
Columbus, Ohio, United States, 432101228 收起 <<
Tanzania
... 展开 >> Ngere Ngere Health Center
Ngere Ngere, Morogoro Rural, Tanzania
Ikwiriri Health Center
Ikwiriri, Rufiji, Tanzania
Lupiro Health Center
Lupiro, Ulanga, Tanzania 收起 <<
Philippines
... 展开 >> Kalinga Health Center
Tabuk, Kalinga Province, Philippines
Davao Health Center
Davao City, Mindinao, Philippines
Palawan Health Center
Puerto Princesa, Palawan, Philippines 收起 <<
Intermittent Preventive Treatm... 展开 >>ent In Pregnancy (IPTp) 收起 <<
Phase 3
Terminated(See termination rea... 展开 >>son in detailed description.) 收起 <<
-
Benin
... 展开 >> Centre de Santé d'AHOUANSORI-AGUE
Cotonou, Benin
Hôpital Bethesda
Cotonou, Benin
Kenya
Siaya District Hospital
Siaya, Kenya
Malawi
Zomba Central Hospital
Zomba, Malawi
Tanzania
Teule Hospital
Muheza, Tanga, Tanzania
Bugando Medical Centre
Mwanza, Tanzania, 1903
Nyamagana District Hospital, c/o National Institute for Medical Research, Mwanza Centre
Mwanza, Tanzania
Nyamagana District Hospital
Mwanza, Tanzania
Uganda
Mulago Hospital Complex
Kampala, Uganda 收起 <<
Terminated(Low prevalence of m... 展开 >>alaria, high prevalence of reported allergy to sulphur drugs, high proportion of women not meeting the inclusion criterea.) 收起 <<
August 2010
Solomon Islands
... 展开 >>
Honiara City Council
Honiara, Solomon Islands 收起 <<
Toxoplasmosis, Cerebral
... 展开 >> HIV Infections 收起 <<
Not Applicable
Completed
-
United States, California
... 展开 >>
Community Consortium of San Francisco
San Francisco, California, United States, 94110
United States, Colorado
Denver CPCRA / Denver Public Hlth
Denver, Colorado, United States, 802044507
United States, Connecticut
Hill Health Corp
New Haven, Connecticut, United States, 06519
United States, Delaware
Wilmington Hosp / Med Ctr of Delaware
Wilmington, Delaware, United States, 19899
United States, Georgia
AIDS Research Consortium of Atlanta
Atlanta, Georgia, United States, 30308
United States, Illinois
AIDS Research Alliance - Chicago
Chicago, Illinois, United States, 60657
United States, Louisiana
Louisiana Comm AIDS Rsch Prog / Tulane Univ Med
New Orleans, Louisiana, United States, 70112
United States, Michigan
Comprehensive AIDS Alliance of Detroit
Detroit, Michigan, United States, 48201
Henry Ford Hosp
Detroit, Michigan, United States, 48202
United States, New Jersey
North Jersey Community Research Initiative
Newark, New Jersey, United States, 071032842
United States, New York
Bronx Lebanon Hosp Ctr
Bronx, New York, United States, 10456
Addiction Research and Treatment Corp
Brooklyn, New York, United States, 11201
Clinical Directors Network of Region II
New York, New York, United States, 10011
Harlem AIDS Treatment Group / Harlem Hosp Ctr
New York, New York, United States, 10037
United States, Oregon
Portland Veterans Adm Med Ctr / Rsch & Education Grp
Portland, Oregon, United States, 972109951
United States, Virginia
Richmond AIDS Consortium
Richmond, Virginia, United States, 23298 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
Terminated(The study was termi... 展开 >>nated because of Early Treatment Failure in child.The justification for this decision are concerns about safety of children.) 收起 <<
-
Gabon
... 展开 >> Medical Research Unit of the Albert Schweitzer Hospital
Lambaréné, Moyen Ogooué, Gabon, B.P. 118 收起 <<
United States, New York
... 展开 >>
New York University, School of Medicine, Department of Neurology
New York, New York, United States, 10016
United States, Ohio
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106
Canada, Ontario
Division of Clinical & Metabolic Genetics, Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8 收起 <<
United States, New York
... 展开 >>
Weill Cornell Medical Center/New York Presbyterian Hospital
New York, New York, United States, 10021
United States, Texas
Methodist Neurological Institute
Houston, Texas, United States, 77030
Germany
Universitäts- und Rehabilitationskliniken Ulm
Ulm, Germany
Italy
Milano Neurological Institute
Milan, Italy
Sweden
Umea University
Umea, Sweden 收起 <<
United States, Massachusetts
... 展开 >>
Beth Israel Deaconess Medical Center
Recruiting
Boston, Massachusetts, United States, 02115
Principal Investigator: Robin Joyce, MD
Dana-Farber Cancer Institute
Recruiting
Boston, Massachusetts, United States, 02115
Principal Investigator: Jennifer Brown, MD, PhD 收起 <<
搜索
