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首页 / 抑制剂/激动剂 / 细胞周期 / DHFR / Levomefolate calcium

左旋甲状腺素钙 /Levomefolate calcium {[allProObj[0].p_purity_real_show]}

货号：A126968 同义名： L-5-甲基四氢叶酸钙

Levomefolate Calcium is an artificial form of folate.

Levomefolate calcium 化学结构 CAS号：151533-22-1
Levomefolate calcium 化学结构
CAS号：151533-22-1
Levomefolate calcium 3D分子结构
CAS号：151533-22-1
Levomefolate calcium 化学结构 CAS号：151533-22-1
Levomefolate calcium 3D分子结构 CAS号：151533-22-1
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Levomefolate calcium 纯度/质量文件 产品仅供科研

货号：A126968 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DHFR ↓ 其他靶点 纯度
Pralatrexate ✔ 99%+
Pemetrexed disodium ++++

DHFR, Ki: 7.2 nM

 		99.9%
Pyrimethamine ++

DHFR, IC50: 15.4 nM

 		98% HPLC
Pemetrexed ++++

DHFR , Ki: 7.2 nM

 		99+%
Methotrexate +

hDHFR, IC50: 24 nM

 		99% (contain ~10%water)
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Levomefolate calcium 生物活性

描述 Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. A fixed-dose combination of an oral contraceptive and levomefolate calcium leads to sustainable improvements in folate status compared with an oral contraceptive + folic acid[3]. Clinically significant increases in folate status were observed with EE/drsp/levomefolate calcium compared with EE(ethinylestradiol)/drsp alone in US women of childbearing age[4]. The rate and extent of absorption of ethinylestradiol and drospirenone were not affected by the concomitant administration of levomefolate calcium and vice versa[5].

Levomefolate calcium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00468481 Neural Tube Defects ... 展开 >> Contraception Oral Contraceptives (OC) 收起 << Phase 3 Completed - United States, California ... 展开 >> Orange County Clinical Trials Anaheim, California, United States, 92801 Medical Center for Clinical Research San Diego, California, United States, 92108 United States, Maryland SNBL Clinical Pharmacology Center, Inc. Baltimore, Maryland, United States, 21201 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina AAIPharma, Inc. Morrisville, North Carolina, United States, 27560 Lyndhurst Gynecologic Associates Winston-Salem, North Carolina, United States, 27103 United States, South Carolina Coastal Carolina Research Center Mt. Pleasant, South Carolina, United States, 29464 United States, Tennessee New Orleans Center for Clinical Research Knoxville, Tennessee, United States, 37920 United States, Washington NorthWest Kinetics Tacoma, Washington, United States, 98418 收起 <<
NCT00468481 - Completed - -
NCT01584050 Vitamin B12 Deficiency Not Applicable Completed - Canada, British Columbia ... 展开 >> University of British Columbia Vancouver, British Columbia, Canada Malaysia Universiti Putra Malaysia Serdang, Selangor, Malaysia 收起 <<

Levomefolate calcium 参考文献

[1]Wiesinger H, Eydeler U, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

[2]Blode H, Klipping C, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception. 2012 Feb;85(2):177-84.

[3]Diefenbach K, Trummer D, Ebert F, Lissy M, Koch M, Rohde B, Blode H. EE-drospirenone-levomefolate calcium versus EE-drospirenone + folic acid: folate status during 24 weeks of treatment and over 20 weeks following treatment cessation. Int J Womens Health. 2013 Apr 11;5:149-63

[4]Bart S Sr, Marr J, Diefenbach K, Trummer D, Sampson-Landers C. Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study. Contraception. 2012 Jan;85(1):42-50

[5]Blode H, Klipping C, Richard F, Trummer D, Rohde B, Diefenbach K. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception. 2012 Feb;85(2):177-84

Levomefolate calcium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.05mL

2.01mL

1.00mL

20.10mL

4.02mL

2.01mL

Levomefolate calcium 技术信息

CAS号151533-22-1
分子式C20H23CaN7O6
分子量 497.518
别名 L-5-甲基四氢叶酸钙
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

H2O: 4 mg/mL(8.04 mM)
动物实验配方

Tags: Levomefolate | 151533-22-1 | Cell Cycle/DNA Damage | Antifolate | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Levomefolate calcium 纯度/质量文件 | Levomefolate calcium 亚型比较 | Levomefolate calcium 生物活性 | Levomefolate calcium 临床数据 | Levomefolate calcium 参考文献 | Levomefolate calcium 实验方案 | Levomefolate calcium 技术信息

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