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首页 / 抑制剂/激动剂 / 细胞周期 / DHFR / Levoleucovorin Calcium

左亚叶酸钙 /Levoleucovorin Calcium {[allProObj[0].p_purity_real_show]}

货号：A161998 同义名： Calcium levofolinate;CL307782

Levoleucovorin Calcium 具有抗肿瘤作用，也是 5-Fluorouracil 抗癌细胞毒性的增强剂。

Levoleucovorin Calcium 化学结构 CAS号：80433-71-2
Levoleucovorin Calcium 化学结构
CAS号：80433-71-2
Levoleucovorin Calcium 3D分子结构
CAS号：80433-71-2
Levoleucovorin Calcium 化学结构 CAS号：80433-71-2
Levoleucovorin Calcium 3D分子结构 CAS号：80433-71-2
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Levoleucovorin Calcium 纯度/质量文件 产品仅供科研

货号：A161998 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DHFR ↓ 其他靶点 纯度
Pralatrexate ✔ 99%+
Pemetrexed disodium ++++

DHFR, Ki: 7.2 nM

 		99.9%
Pyrimethamine ++

DHFR, IC50: 15.4 nM

 		98% HPLC
Pemetrexed ++++

DHFR , Ki: 7.2 nM

 		99+%
Methotrexate +

hDHFR, IC50: 24 nM

 		99% (contain ~10%water)
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Levoleucovorin Calcium 生物活性

描述 Calcium Levofolinate is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid. Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer. Levoleucovorin is also used in combination chemotherapy with fluorouracil (5-FU) to treat colorectal cancer that has spread to other parts of the body. This medicine only treats the symptoms of colorectal cancer and does not treat the cancer itself. In the combination of Leucovorin (LV) and 5-fluorouracil (5-FU), LV potentiates the cytotoxic effect of 5-FU based on biochemical modulation[3]. A 4-week toxicity study of 5-FU (10 mg/kg/day) in combination with 1-LV (6, 20 or 60 mg/kg/day) was conducted in rats. In the group for which 5-FU was combined with 1-LV, the RBC counts decreased, extramedullary hematopoiesis increased and the suppression of lymphatic organs was enhanced. Changes in the lymphatic organs were observed at 20 mg/kg/day of 1-LV and above. The potentiation induced by 1-LV in the toxicity of 5-FU appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-FU[4].

Levoleucovorin Calcium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02047474 Acinar Cell Adenocarcinoma of ... 展开 >>the Pancreas Duct Cell Adenocarcinoma of the Pancreas Stage I Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer 收起 << Phase 2 Recruiting December 2020 United States, Connecticut ... 展开 >> Yale University Recruiting New Haven, Connecticut, United States, 06520-8032 Contact: Kamil Sadowski    203-785-6661    kamil.sadowski@yale.edu    Principal Investigator: Jill Lacy 收起 <<
NCT01320683 Liver Metastases ... 展开 >> Recurrent Colon Cancer Recurrent Rectal Cancer Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer 收起 << Phase 2 Terminated(Slow accrual.) - United States, California ... 展开 >> City of Hope Medical Center Duarte, California, United States, 91010 收起 <<
NCT01959139 Metastatic Pancreatic Adenocar... 展开 >>cinoma 收起 << Phase 1 Phase 2 Active, not recruiting October 2020 -

Levoleucovorin Calcium 参考文献

[1]Willems FF, Boers GH, et al. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol. 2004 Mar;141(5):825-30.

[2]Murakami Y, Fujii H, et al. Effects of levofolinate calcium on subacute intravenous toxicity of 5-fluorouracil in rats. J Toxicol Sci. 1998 May;23 Suppl 1:11-29.

[3]Sasaki T. [Combination of levofolinate calcium and 5-fluorouracil]. Gan To Kagaku Ryoho. 2000 Feb;27(2):315-22. Japanese

[4]Murakami Y, Fujii H, Ichimura A, Murata A, Yamashita N, Takagi H, Tauchi K. Effects of levofolinate calcium on subacute intravenous toxicity of 5-fluorouracil in rats. J Toxicol Sci. 1998 May;23 Suppl 1:11-29

Levoleucovorin Calcium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.74mL

1.95mL

0.97mL

19.47mL

3.89mL

1.95mL

Levoleucovorin Calcium 技术信息

CAS号80433-71-2
分子式C20H23CaN7O7
分子量 513.517
别名 Calcium levofolinate;CL307782;5-Formyltetrahydrofolate;L-Folinate;L-Folinic Acid (calcium salt)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

H2O: 10 mg/mL(19.47 mM)，配合低频超声助溶
动物实验配方

Tags: Levoleucovorin | 80433-71-2 | Calcium levofolinate | CL307782 | CL307782 | CL 307782 | CL-307782 | Cell Cycle/DNA Damage | Antifolate | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Levoleucovorin Calcium 纯度/质量文件 | Levoleucovorin Calcium 亚型比较 | Levoleucovorin Calcium 生物活性 | Levoleucovorin Calcium 临床数据 | Levoleucovorin Calcium 参考文献 | Levoleucovorin Calcium 实验方案 | Levoleucovorin Calcium 技术信息

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