Ambeed.cn

首页 / / / / Folinic acid calcium

亚叶酸钙 /Folinic acid calcium {[allProObj[0].p_purity_real_show]}

货号:A161719 同义名: 亚叶酸钙 / Leucovorin calcium;Calcium folinate

Leucovorin calcium is a reduced form of folic acid.

Folinic acid calcium 化学结构 CAS号:1492-18-8
Folinic acid calcium 化学结构
CAS号:1492-18-8
Folinic acid calcium 3D分子结构
CAS号:1492-18-8
Folinic acid calcium 化学结构 CAS号:1492-18-8
Folinic acid calcium 3D分子结构 CAS号:1492-18-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Folinic acid calcium 纯度/质量文件 产品仅供科研

货号:A161719 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

Cell Host Microbe, 2024. Ambeed. [ A163338 ]
Cancer Res., 2024. Ambeed. [ A295334 ]
J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >
产品名称 DHFR 其他靶点 纯度
Pralatrexate 99%+
Pemetrexed disodium ++++

DHFR, Ki: 7.2 nM

99.9%
Pyrimethamine ++

DHFR, IC50: 15.4 nM

98% HPLC
Pemetrexed ++++

DHFR , Ki: 7.2 nM

99+%
Methotrexate +

hDHFR, IC50: 24 nM

99% (contain ~10%water)
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Folinic acid calcium 生物活性

描述 Calcium Folinate (CF) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX (methotrexate) in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX[3]. Uracil and tegafur (UFT) plus calcium folinate are the components of the oral agent known as Orzel, which offers activity comparable to intravenously administered 5-fluorouracil (5-FU) combined with calcium folinate[4]. UFT (uracil and tegafur) plus oral calcium folinate (Orzel) offers significant antitumor activity and an acceptable toxicity profile makes this a logical formulation for the adjuvant treatment of colon cancer[5]. Furthermore, tegafur/uracil + calcium folinate is well tolerated, with dose-limiting toxicity manifesting as diarrhoea. Compared with intravenous fluorouracil plus folinic acid (leucovorin) regimens, tegafur/uracil + calcium folinate has similar efficacy with less toxicity and is more convenient because it is an oral regimen[6].

Folinic acid calcium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00591045 Stomach Neoplasms ... 展开 >> Gastric Cancer 收起 << Phase 2 Unknown December 2012 China, Beijing ... 展开 >> Peking University School of Oncology Not yet recruiting Beijing, Beijing, China, 100036 Contact: Jiafu Ji, M.D.    86-10-88196048    jiafuj@hotmail.com    Principal Investigator: Jiafu Ji, M.D. 收起 <<
NCT02573220 Stage IVA Colorectal Cancer ... 展开 >> Stage IVB Colorectal Cancer 收起 << Phase 1 Withdrawn(Study terminated by ... 展开 >>PI due to inability to accrue.) 收起 << - Italy ... 展开 >> Centro di Riferimento Oncologico Aviano, Italy, 33081 收起 <<
NCT00677287 Colorectal Cancer ... 展开 >> Colon Cancer Rectal Cancer 收起 << Phase 1 Phase 2 Terminated(Lack of financial s... 展开 >>upport) 收起 << - Japan ... 展开 >> The Institute of Medical Science, the University of Tokyo Minato-ku, Tokyo, Japan, 108-8639 收起 <<

Folinic acid calcium 参考文献

[1]Chang WN, Tsai JN, et al. Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2127-37.

[2]Schilsky RL, Ratain MJ. Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. J Natl Cancer Inst. 1990 Sep 5;82(17):1411-5.

[3]Yang XJ, Chen YP, Wang HC, Zhao J, Zheng FY. Protective effect of calcium folinate against methotrexate-induced endosalpinx damage in rats. Fertil Steril. 2011 Mar 15;95(4):1526-30

[4]Bokemeyer C, Hartmann JT, Kollmannsberger C, Mayer F, Kanz L. UFT/calcium folinate plus weekly paclitaxel for solid tumors. Oncology (Williston Park). 1999 Jul;13(7 Suppl 3):106-11

[5]Smith R, Wickerham DL, Wieand HS, Colangelo L, Mamounas EP. UFT plus calcium folinate vs 5-FU plus calcium folinate in colon cancer. Oncology (Williston Park). 1999 Jul;13(7 Suppl 3):44-7

[6]Hoff PM, Lassere Y, Pazdur R. Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil. Drugs. 1999;58 Suppl 3:77-83

Folinic acid calcium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.96mL

0.39mL

0.20mL

9.78mL

1.96mL

0.98mL

19.55mL

3.91mL

1.96mL

Folinic acid calcium 技术信息

CAS号1492-18-8
分子式C20H21CaN7O7
分子量 511.501
别名 亚叶酸钙 ;Leucovorin calcium;Calcium folinate;5-Formyltetrahydrofolate;NSC 3590;DL-Folinate;DL-Folinic Acid (calcium salt);Wellcovorin;Folinic acid calcium salt
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

H2O: 50 mg/mL(97.75 mM),配合低频超声助溶

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。