Thalidomide-5-NH2-CH2-COOH是一种有效的、选择性的原肌球蛋白受体激酶 (trk) 抑制剂。Thalidomide-5-NH2-CH2-COOH 是 E3 连接酶的配体。Thalidomide-5-NH2-CH2-COOH 具有研究一种或多种疾病的潜力

ALE-0540是一种神经生长因子受体 (NGFR) 拮抗剂，能够抑制 NGF 与 TrkA 受体的结合，具有用于疼痛治疗机制研究的潜力。

ANA-12 是一种选择性的 TrkB 受体拮抗剂，对 TrkB 的 IC50 值为 45 nM。ANA-12 具有神经保护和抗抑郁作用，可用于神经退行性疾病和情感障碍的研究。

LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.

LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor. It can improve survival and increase neurite outgrowth in vitro.

GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively).

GW 441756 is an inhibitor of tropomyosin-related kinase A (TrkA) with IC50 of 2 nM.

LM22A-4 is a specific agonist oftyrosine kinase receptor B.

CH7057288是一种有效的 TRK 抑制剂，具有治疗 TRK 重排肿瘤的潜力。

N-Acetyl-5-hydroxytryptamine是一种5-HT前体，能激活TrkB受体，参与神经保护和调节神经递质的研究。

LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.

Belizatinib 是一种有效的、口服可用的双重ALK和TRK抑制剂，对野生型重组ALK的IC50值为0.7 nM。

Taletrectinib is a new-generation selective ROS1/Trk Receptor inhibitor with IC50 values of 0.207nM, 0.622nM, 2.28nM and 0.98nM for ROS1, Trk Receptor A, B and C, respectively. It induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo.

Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc.

Altiratinib is a c-MET/TIE-2/VEGFR inhibitor which effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

Entrectinib（NMS-E628）是一种口服有效的、可穿透血脑屏障的TrkA/B/C、ROS1和ALK抑制剂，对它们的IC50值分别为1、3、5、12和7 nM。它在癌细胞中诱导凋亡和细胞周期停滞，显示出抗肿瘤活性，并减轻小鼠中博来霉素引起的肺纤维化。

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect.

LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC.