Minodronic acid monohydrate是一种法尼基二磷酸合成酶抑制剂，可作为骨吸收抑制剂。

High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

GGTI298 trifluoroacetate is geranylgeranyltransferase I inhibitor. It shows supression of the G1 phase of the cell cycle and induction of apoptosis.

L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase.

L-778123 hydrochloride 是 FPTase 和 GGPTase-I 的抑制剂，在酶抑制测定中的 IC50 分别为 2 nM 和 98 nM。

K-604 is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor. K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC50 = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner.

L-Glutamic acid γ-(p-nitroanilide) HCl is a substrate for GGT (gamma-glutamyltransferase), which is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor.

SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.

AG-270 is a first-in-Class Oral MAT2A Inhibitor.

GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1].

Tipifarnib is an inhibitor of farnesyltransferase with IC50 of 0.6 nM.

GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM.

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1].

PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively.

AG-270 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with potential antineoplastic activity.

Benzoyleneurea scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors.

(R)-(+)-etomoxir sodium salt is inhibitor of carnitine palmitoyltransferase I (CPT1) and can reduce β-oxidation in mitochondria. It shows inhibition of cardiolipin biosynthesis.

EPZ015666 (GSK3235025) 是一种口服活性的PRMT5抑制剂，IC50为22 nM。

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug.