Sigma-1 receptor antagonist 2是一种有效的选择性 sigma 1 受体 (σ1R) 拮抗剂，对 σ1 和 σ2 受体的 Ki 值分别为 3.88 和 1288 nM。

Sigma-1 receptor antagonist 3是一种高效的 Sigma-1 受体拮抗剂，Ki 为 1.14 nM，具有用于神经性疼痛研究的潜力。

Glycerol phenylbutyrate (GPB)是一种 σ2 受体配体，pKi 值为 8.02，并作为新一代氨清除剂发挥作用。

Sigma-1 receptor antagonist 1是一种选择性的 sigma-1 受体

Rimcazole 2HCl 是一种咔唑衍生物，部分用作 σ 受体拮抗剂。它以中等亲和力结合多巴胺转运蛋白并抑制多巴胺摄取，从而减弱运动活动和致敏作用，也可用于癌症研究。

BMY 14802是一种 sigma-1 受体 (σ1R) 的拮抗剂，同时也是 5-HT 1A 受体和 α-1 肾上腺素能受体的激动剂。该化合物在帕金森病 (PD) 的大鼠模型中可抑制异常不自主运动 (AIM)，并下调其表达，适用于帕金森病的研究。

(±)-Vesamicol 盐酸盐 ((±)-AH5183 盐酸盐) 是一种有效的囊泡乙酰胆碱转运抑制剂，其 Ki 为 2 nM。(±)-Vesamicol 盐酸盐还对 σ1 和 σ2 受体具有高亲和力，其 Ki 值分别为 26 nM 和 34 nM。

Siramesine HCl is an agonist of sigma-2 receptor which can trigger cell death and exhibit anticancer activity.

S1RA is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.

σ1 Receptor antagonist-1是一种高选择性的 Sigma 1 受体拮抗剂，能够诱导细胞凋亡，对神经退行性疾病有研究价值。

BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

S1RA HCl is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).

Pridopidine exhibits high affinity towards sigma 1 receptor (S1R) (Ki = 70-80 nM) which can counteract the effects of excessive or insufficient dopaminergic transmission and it can used as a dopamine (DA) stabilizer.

Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor)[1].

σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.

PRE-084 盐酸盐是一种高选择性的 σ1 受体（S1R）激动剂，其 IC50 值为 44 nM。

SA4503 is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.

Roluperidone is a 5-HT2A and sigma 2 receptor antagonist.