货号:A725023 同义名: BD1063 dihydrochloride;BD1063 dhydrochloride
BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
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描述 | BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. BD-1063 dose dependently reduced ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that did not modify mean ethanol self-administration in nondependent Wistar controls. BD-1063 also reduced the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule[1]. BD-1063 dose-dependently reduced binge-like eating and the regularity of food responding, and blocked the increased eating rate in Palatable rats. In the light/dark conflict test, BD-1063 antagonized the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity[2]. In endothelial cells, 10-100 μM of the Sig1R antagonist BD1063 inhibited sustained but not transient calcium responses evoked by histamine[3]. BD1063 treatment was able to preserve neuromuscular function of the hindlimbs and increased the number of surviving MNs (motoneurons) in the treated female SOD1G93A mice[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.89mL 0.58mL 0.29mL |
14.45mL 2.89mL 1.44mL |
28.89mL 5.78mL 2.89mL |
CAS号 | 206996-13-6 |
分子式 | C13H20Cl4N2 |
分子量 | 346.123 |
别名 | BD1063 dihydrochloride;BD1063 dhydrochloride;BD 1063 (hydrochloride);BD1063 2HCL |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
H2O: 100 mg/mL(288.91 mM),配合低频超声助溶 |
动物实验配方 |