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描述 | Sigma-1 receptor antagonist 1 is a highly potent and selective antagonist for the sigma-1 receptor (σ1R), displaying strong affinity (Ki = 1.06 nM) for the σ1R receptor. It demonstrates antineuropathic pain efficacy, making it a promising candidate for neuropathic pain management[1]. |
体内研究 | Sigma 1 receptor antagonist 1 produces antinociceptive effects that vary with dosage in mouse formalin tests and rat CCI models of neuropathic pain[1]. |
体外研究 | Sigma 1 receptor antagonist 1 demonstrates a high affinity for the σ1R receptor (Ki = 1.06 nM) and notable selectivity between σ-1 and σ-2 receptors (1344-fold)[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.63mL 0.53mL 0.26mL |
13.15mL 2.63mL 1.31mL |
26.29mL 5.26mL 2.63mL |
CAS号 | 1639220-19-1 |
分子式 | C19H23Cl2N3O |
分子量 | 380.311 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 5 mg/mL(13.15 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |