货号:A711600 同义名: Anavex 2-73;Blarcamesine hydrochloride
σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.
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Animal study | Pre-administration of Blarcamesine HCl results in a dose-dependent attenuation of scopolamine-induced alternation deficits, significant at doses of 1 and 3 mg/kg. Blarcamesine HCl pretreatment can mitigate the damage to step-through latency, showing dose-dependency and significance at doses above 0.3 mg/kg[1]. Blarcamesine HCl treatment dose-dependently blocks recognition memory deficits, with significant effects observed at a dose of 1 mg/kg. One day post-injection, Blarcamesine HCl at doses of 0.1 and 1 mg/kg significantly weakens the reduction of Akt phosphorylation induced by Aβ25-35. Seven days post-injection, Blarcamesine HCl at 0.3 and 1 mg/kg can attenuate the peptide-induced decrease in Ser9 phosphorylation. Blarcamesine HCl treatment dose-dependently prevents the increase in Aβ1-42 levels induced by Aβ25-35, with significant effects at the highest tested dose[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.15mL 0.63mL 0.31mL |
15.73mL 3.15mL 1.57mL |
31.46mL 6.29mL 3.15mL |
CAS号 | 195615-84-0 |
分子式 | C19H24ClNO |
分子量 | 317.85 |
别名 | Anavex 2-73;Blarcamesine hydrochloride;AE-37 hydrochloride;AVex-73 hydrochloride;Anavex 2-73 HCl |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 25 mg/mL(78.65 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(314.61 mM),配合低频超声助溶 |
动物实验配方 |