SA 4503 二盐酸盐 /Cutamesine 2HCl
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货号：A260566
同义名：
库他美新二盐酸盐
/ SA4503 dihydrochloride;AGY94806 dihydrochloride
SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM.
Cutamesine 2HCl 化学结构
Cutamesine 2HCl 3D分子结构
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Cutamesine 2HCl 纯度/质量文件 产品仅供科研
货号：A260566
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Cutamesine 2HCl 质控信息
Cutamesine 2HCl 生物活性
描述
SA4503 dihydrochloride is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. SA4503 is 14-fold selective for sigma(1) (K(i) = 4.6 nM) over sigma(2) (K(i) = 63.1 nM) sites in guinea pig brain homogenates[3] [4] [5] [6]
Cutamesine 2HCl 参考文献
[1] Shimazawa M, Sugitani S, et al. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72.
[2] Matsuno K, Nakazawa M, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9.
[3] Lever JR, Gustafson JL, Xu R, Allmon RL, Lever SZ. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8
[4] Tuerxun T, Numakawa T, Adachi N, Kumamaru E, Kitazawa H, Kudo M, Kunugi H. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8
[5] Tagashira H, Matsumoto T, Taguchi K, Zhang C, Han F, Ishida K, Nemoto S, Kobayashi T, Fukunaga K. Vascular endothelial σ1-receptor stimulation with SA4503 rescues aortic relaxation via Akt/eNOS signaling in ovariectomized rats with aortic banding. Circ J. 2013;77(11):2831-40
[6] Yamaguchi K, Shioda N, Yabuki Y, Zhang C, Han F, Fukunaga K. SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome. Int J Mol Sci. 2018 Sep 18;19(9):2811
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Cutamesine 2HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.27mL
0.45mL
0.23mL
11.33mL
2.27mL
1.13mL
22.65mL
4.53mL
2.27mL
Cutamesine 2HCl 技术信息
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