Travoprost is a synthetic prostaglandin F2α analog as a potent and selective FP prostaglandin receptor agonist, used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.
Prostaglandin (PG) F(2α) is widely distributed in various organs and exhibits various biological functions, such as luteolysis, parturition, aqueous humor homeostasis, vasoconstriction, rennin secretion, pulmonary fibrosis[3]. Travoprost, a highly selective and potent analogue of the prostaglandin PGF(2α), has recently been approved and marketed as a topical ocular hypotensive agent for the treatment of ocular hypertension and glaucoma [4]. Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0. 01, 0. 03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg[5]. As assessed with YO-PRO-1 and Hoechst 33342 relative to cell viability determined with NR or AB, travoprost/timolol PQ produced significantly less apoptosis than travoprost/timolol BAK and latanoprost/timolol BAK and their respective BAK concentrations alone (P<0. 0001 for all) [6].
Open Angle Glaucoma
... 展开 >> Ocular Hypertension 收起 <<
Phase 2
Completed
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United States, California
... 展开 >>
Kenneth Sall, M.D.
Artesia, California, United States, 90701
United Medical Research Institute
Inglewood, California, United States, 90301
Aesthetic Eye Care Institute
Newport Beach, California, United States, 92657
Bacharach practice
Petaluma, California, United States, 94954
Centre For Health Care
Poway, California, United States, 92064
United States, Georgia
Clayton Eye Center
Morrow, Georgia, United States, 30260
Coastal Research Associates, LLC
Roswell, Georgia, United States, 30076
United States, Kansas
Bradley Kwapiszeski, MD
Shawnee Mission, Kansas, United States, 66204
United States, Kentucky
Taustine Eye Center
Louisville, Kentucky, United States, 40217
United States, Maryland
Alan L Robin, M.D.
Baltimore, Maryland, United States, 21209
Seidenberg Protzko Eye Associates
Havre de Grace, Maryland, United States, 21078
United States, Michigan
Great Lakes Eye Care
St Joseph, Michigan, United States, 49085
United States, New York
Jeffrey Schultz, M.D.
Bronx, New York, United States, 10467
Ophthalmic Consultants of Long Island
Lynbrook, New York, United States, 11563
Rochester Ophthalmological Group
Rochester, New York, United States, 14618
United States, North Carolina
Charlotte Eye Ear Nose & Throat Associates, P.A.
Belmont, North Carolina, United States, 28012
United States, Oklahoma
The Eye Institute
Tulsa, Oklahoma, United States, 74104
United States, Texas
Texan Eye
Austin, Texas, United States, 78731
Medical Center Ophth. Associates
San Antonio, Texas, United States, 78731
United States, Utah
Stacy R. Smith, M.D.
Salt Lake City, Utah, United States, 84117
United States, Virginia
Virginia Eye Consultants
Norfolk, Virginia, United States, 23502 收起 <<
United States, California
... 展开 >>
Doheny Eye Institute
Los Angeles, California, United States, 90033-4666
United States, Connecticut
The Eye Center
Hamden, Connecticut, United States, 06518
United States, Florida
University of Florida
Gainesville, Florida, United States, 32610
United States, Georgia
Emory Healthcare Eye Center
Atlanta, Georgia, United States, 30322
Omni Eye Services
Atlanta, Georgia, United States, 30342
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
University of Illinois Eye and Ear Infirmary
Chicago, Illinois, United States, 60612
United States, Indiana
Indiana University School of Medicine
Indianapolis, Indiana, United States, 46202
United States, Massachusetts
Glaucoma Consultation Service
Boston, Massachusetts, United States, 02114
United States, Michigan
Kresge Eye Institute
Detroit, Michigan, United States, 48201
United States, Mississippi
Mississippi Eye Associates
Ocean Springs, Mississippi, United States, 39564
United States, New York
Eyecare Ophthalmology PC
Bethpage, New York, United States, 11714
Mount Sinai School of Medicine
New York, New York, United States, 10029
United States, Oklahoma
Dean McGee Eye Institute
Oklahoma City, Oklahoma, United States, 73104
United States, Pennsylvania
Wills Eye Institute
Philadelphia, Pennsylvania, United States, 19107
The Keystone Eye Associates
Philadelphia, Pennsylvania, United States, 19114
United States, Texas
Glaucoma Associates of Texas
Dallas, Texas, United States, 75231
Baylor College of Medicine
Houston, Texas, United States, 77030
Hermann Eye Center
Houston, Texas, United States, 77030
Lone Star Eye Associates
Sugarland, Texas, United States, 77479
United States, West Virginia
West Virginia University Eye Institute
Morgantown, West Virginia, United States, 26506 收起 <<
United States, New York
... 展开 >>
Ophthalmic Consultants of Long Island
East Meadow, New York, United States, 11554
Ophthalmic Consultants of Long Island
Lynbrook, New York, United States, 11563
Ophthalmic Consultants of Long Island
Rockville Centre, New York, United States, 11570
Ophthalmic Consultants of Long Island
Stony Brook, New York, United States, 11790
Ophthalmic Consultants of Long Island
Valley Stream, New York, United States, 11581 收起 <<
United States, California
... 展开 >>
United Medical Research Institute
Inglewood, California, United States, 90301
Aesthetic Eye Care Institute
Newport Beach, California, United States, 92657
Bacharach practice
Petaluma, California, United States, 94954
Centre For Health Care
Poway, California, United States, 92064
United States, Missouri
Comprehensive Eye Care
St Louis, Missouri, United States, 63090
United States, New York
Rochester Ophthalmology Group
Rochester, New York, United States, 14618
Glaucoma Consultants of the Capital Region
Slingerlands, New York, United States, 12159
United States, Ohio
Abrams Eye Center
Cleveland, Ohio, United States, 44115
United States, Texas
Cataract & Glaucoma Center
El Paso, Texas, United States, 79902 收起 <<
United States, South Dakota
... 展开 >>
Vance Thompson Vision
Recruiting
Sioux Falls, South Dakota, United States, 57108
Contact: John P Berdahl, M.D. 605-361-3937 john.berdahl@vancethompsonvision.com 收起 <<
Glaucoma
Appl... 展开 >>ication Site Pigmentation Changes 收起 <<
Phase 4
Completed
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United States, Illinois
... 展开 >>
Arlington Eye Physicians
Arlington Heights, Illinois, United States, 60005
United States, Ohio
Summa Health System
Akron, Ohio, United States, 44304 收起 <<
United States, Arizona
... 展开 >>
Chandler, Arizona, United States, 85225
United States, California
Garden Grove, California, United States, 92843
Inglewood, California, United States, 90301
Redding, California, United States, 96002
United States, Georgia
Morrow, Georgia, United States, 30260
United States, Indiana
Indianapolis, Indiana, United States, 46260
United States, Missouri
Chesterfield, Missouri, United States, 63017
Kansas City, Missouri, United States, 64133
United States, Ohio
Cincinnati, Ohio, United States, 45242
United States, Oregon
Portland, Oregon, United States, 97210
United States, South Dakota
Sioux Falls, South Dakota, United States, 57108
United States, Texas
Austin, Texas, United States, 78731
Houston, Texas, United States, 77025
San Antonio, Texas, United States, 78229 收起 <<
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