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抑制剂/激动剂
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NF-κB
帕金森与阿尔茨海默症 肿瘤干细胞 PPARs Wnt 细胞焦亡
/ NF-κB / α-Lipoic Acid

α-硫辛酸 /α-Lipoic Acid {[allProObj[0].p_purity_real_show]}

货号：A196877 同义名： DL-硫辛酸 / Thioctic acid;DL-α-Lipoic acid

α-Lipoic Acid is a naturally occuring vitamin-like antioxidant.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
α-Lipoic Acid 化学结构 CAS号：1077-28-7
α-Lipoic Acid 化学结构
CAS号：1077-28-7
α-Lipoic Acid 3D分子结构
CAS号：1077-28-7
α-Lipoic Acid 化学结构 CAS号：1077-28-7
α-Lipoic Acid 3D分子结构 CAS号：1077-28-7
规格 价格 会员价 库存 数量
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α-Lipoic Acid 纯度/质量文件 产品仅供科研

货号：A196877 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
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更多 >
产品名称 NF-κB ↓ 其他靶点 纯度
PDTC ammonium ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ HDAC,Nrf2 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

α-Lipoic Acid 生物活性

描述 α-Lipoic Acid, a naturally occurring substance, has many biological activities[1]. In vitro studies, α-lipoic acid could increase the level of PON1 and PON3 protein, as well as regulate their mRNA expression in HepG2 cells[2]. Besides this, it was found that α-lipoic acid had good antioxidant activity in C2C12 myotubes, through upregulating catalase expression[3]. In vivo studies, α-lipoic acid has the ability of protecting the cortical neurons against the high-fat diet-induced cerebral damage in mice, by inhibiting the oxidative stress and inflammatory reactions[4]. In addition, α-lipoic acid could contribute to the mitigation of α-cypermethrin-induced toxicity in cerebellum of treated rats[5].

α-Lipoic Acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01931787 Recurrent Small Cell Lung Canc... 展开 >>er 收起 << Phase 1 Completed - United States, North Carolina ... 展开 >> Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina, United States, 27157 收起 <<
NCT01471652 Chronic Fatigue Syndrome Phase 2 Withdrawn(PI left the institut... 展开 >>ion) 收起 << - United States, New York ... 展开 >> Columbia University Department of Clinical Genetics New York, New York, United States, 10032 收起 <<
NCT00664001 Acute Mountain Sickness Phase 3 Completed - United Kingdom ... 展开 >> University of Edinburgh Edinburgh, United Kingdom 收起 <<

α-Lipoic Acid 参考文献

[1]Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr. 2014;6(1):80.

[2]Ozgun E, Sayilan Ozgun G, et al. Effect of lipoic acid on paraoxonase-1 and paraoxonase-3 protein levels, mRNA expression and arylesterase activity in liver hepatoma cells. Gen Physiol Biophys. 2017;36(4):465-470.

[3]Lee CT, Chang LC, Wu PF. Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes. Inflammation. 2016;39(3):1160-8.

[4]Liu Y, Zhang Q, et al. The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction. Environ Toxicol Pharmacol. 2017.

[5]Elsawy H, Al-Omair MA, et al. Protective effect of α-lipoic acid against α-cypermethrin-induced changes in rat cerebellum. J Chem Neuroanat. 2017.

α-Lipoic Acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.48mL

24.23mL

4.85mL

2.42mL

48.47mL

9.69mL

4.85mL

α-Lipoic Acid 技术信息

CAS号1077-28-7
分子式C8H14O2S2
分子量 206.33
别名 DL-硫辛酸 ;Thioctic acid;DL-α-Lipoic acid;(±)-α-Lipoic acid
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(508.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: α-Lipoic Acid | Thioctic acid;DL-α-Lipoic acid;(±)-α-Lipoic acid | DL-硫辛酸 | NF-κB | AmBeed-信号通路专用抑制剂 | α-Lipoic Acid 纯度/质量文件 | α-Lipoic Acid 亚型比较 | α-Lipoic Acid 生物活性 | α-Lipoic Acid 临床数据 | α-Lipoic Acid 参考文献 | α-Lipoic Acid 实验方案 | α-Lipoic Acid 技术信息

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