生物活性 | |||
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描述 | α-Lipoic Acid, a naturally occurring substance, has many biological activities[1]. In vitro studies, α-lipoic acid could increase the level of PON1 and PON3 protein, as well as regulate their mRNA expression in HepG2 cells[2]. Besides this, it was found that α-lipoic acid had good antioxidant activity in C2C12 myotubes, through upregulating catalase expression[3]. In vivo studies, α-lipoic acid has the ability of protecting the cortical neurons against the high-fat diet-induced cerebral damage in mice, by inhibiting the oxidative stress and inflammatory reactions[4]. In addition, α-lipoic acid could contribute to the mitigation of α-cypermethrin-induced toxicity in cerebellum of treated rats[5]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01931787 | Recurrent Small Cell Lung Canc... 展开 >>er 收起 << | Phase 1 | Completed | - | United States, North Carolina ... 展开 >> Comprehensive Cancer Center of Wake Forest University Winston-Salem, North Carolina, United States, 27157 收起 << |
NCT01471652 | Chronic Fatigue Syndrome | Phase 2 | Withdrawn(PI left the institut... 展开 >>ion) 收起 << | - | United States, New York ... 展开 >> Columbia University Department of Clinical Genetics New York, New York, United States, 10032 收起 << |
NCT00664001 | Acute Mountain Sickness | Phase 3 | Completed | - | United Kingdom ... 展开 >> University of Edinburgh Edinburgh, United Kingdom 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.85mL 0.97mL 0.48mL |
24.23mL 4.85mL 2.42mL |
48.47mL 9.69mL 4.85mL |
参考文献 |
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