Z-DEVD-FMK

产品说明书

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Chemical Structure| 210344-95-9 同义名 : Caspase-3 Inhibitor
CAS号 : 210344-95-9
货号 : A301584
分子式 : C30H41FN4O12
纯度 : 98%
分子量 : 668.665
MDL号 : MFCD23380217
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(74.78 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

2% DMSO+30% PEG 400+5% Tween 80+water 1 mg/mL

生物活性
靶点

  • Caspase-3
描述 Z-DEVD-FMK is an irreversible caspase-3 inhibitor with specificity, having an IC50 of 18 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.50mL

0.30mL

0.15mL

7.48mL

1.50mL

0.75mL

14.96mL

2.99mL

1.50mL
参考文献

[1]Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov

[2]Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32.

[3]Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424.