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舒噻嗪 /Sultiame {[allProObj[0].p_purity_real_show]}

货号:A637802 同义名: Sulthiame Ambeed 开学季,买赠积分,赢豪礼

Sultiame is an inhibitor of carbonic anhydrase that used to treat epilepsy.

Sultiame 化学结构 CAS号:61-56-3
Sultiame 化学结构
CAS号:61-56-3
Sultiame 3D分子结构
CAS号:61-56-3
Sultiame 化学结构 CAS号:61-56-3
Sultiame 3D分子结构 CAS号:61-56-3
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Sultiame 纯度/质量文件 产品仅供科研

货号:A637802 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Carbonic Anhydrase Carbonic Anhydrase I Carbonic Anhydrase II Carbonic Anhydrase IV Carbonic Anhydrase IX Carbonic Anhydrase XII 其他靶点 纯度
Topiramate Calcium Channel {[allProObj[0].p_purity_real_show]}
Dichlorphenamide {[allProObj[0].p_purity_real_show]}
Mafenide Acetate {[allProObj[0].p_purity_real_show]}
Benzenesulphonamide {[allProObj[0].p_purity_real_show]}
Dorzolamide HCl +

Carbonic anhydrase I, Ki: 6000 nM

++++

Carbonic anhydrase II, Ki: 1.9 nM

+++

Carbonic anhydrase IV, Ki: 31 nM

{[allProObj[0].p_purity_real_show]}
Methazolamide ++

hCAI, Ki: 50 nM

+++

hCAII, Ki: 14 nM

++

bCAIV, Ki: 36 nM

{[allProObj[0].p_purity_real_show]}
Tioxolone +

CAI, Ki: 91 nM

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U-104 ++

CAIX, Ki: 45.1 nM

++++

CAXII, Ki: 4.5 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Sultiame 生物活性

描述 Sultiame is a carbonic anhydrase (CA) inhibitor, widely used as an antiepileptic drug[2]. CA inhibitors (CAIs) such as acetazolamide, methazolamide, topiramate, zonisamide, and sulthiame (Sultiame) can reduce seizures through perturbation of the CO(2) equilibrium and/or the inhibition of ion channels[3]. Drugs inhibiting metabolism include antibiotic macrolides, chloramphenicol, isoniazide, some sulphonamides, propoxyphene, cimetidine, valproic acid and sulthiame. Anti-epileptic drugs can induce hepatic microsomal enzymes and, therefore, may increase metabolism of corticosteroids, oral contraceptives, oral anticoagulants, cardiovascular agents, antibiotics, chemotherapeutic agents, psychotropic drugs and non-opiate analgesics, thereby reducing their efficacy[4]. The high tolerability, efficacy, convenience of use and low cost suggest that sulthiame should become a first line drug in the benign partial epilepsies of childhood and juvenile myoclonic epilepsy. It also has a role as add-on treatment in other partial and myoclonic epilepsies[5].

Sultiame 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03400189 Epilepsy Phase 1 Active, not recruiting August 30, 2018 Switzerland ... 展开 >> Division of Clinical Pharmacology Lausanne, Vaud, Switzerland, 1011 收起 <<
NCT00471744 Epilepsy, Rolandic Phase 3 Terminated(low patient number ... 展开 >>after 2 years recruiting) 收起 << - Germany ... 展开 >> Dr. von Haunersches Kinderspital München, Germany, 81371 收起 <<

Sultiame 参考文献

[2]Milburn-McNulty P, Powell G, Sills GJ, Marson AG. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472

[3]Aggarwal M, Kondeti B, McKenna R. Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opin Ther Pat. 2013;23(6):717-24

[4]Pisani F, Perucca E, Di Perri R. Clinically relevant anti-epileptic drug interactions. J Int Med Res. 1990 Jan-Feb;18(1):1-15

[5]Ben-Zeev B, Watemberg N, Lerman P, Barash I, Brand N, Lerman-Sagie T. Sulthiame in childhood epilepsy. Pediatr Int. 2004 Oct;46(5):521-4

Sultiame 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.44mL

0.69mL

0.34mL

17.22mL

3.44mL

1.72mL

34.44mL

6.89mL

3.44mL

Sultiame 技术信息

CAS号61-56-3
分子式C10H14N2O4S2
分子量 290.359
别名 Sulthiame
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(172.2 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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