Nuezhenide (Specneuzhenide) is a phenol glycoside isolated from Ligustrum sinense. Nuezhenide (Specneuzhenide) possesses anti-tumor activity[3]. NZD (Nuezhenide) exhibited anti-inflammatory activity and reduced the release of inflammatory cytokines such as nitrite, TNF-α, and IL-6. NZD suppressed the expression of the phosphorylated proteins like IKKα/β, IκBα, and p65. Besides, the flow cytometry results indicated that NZD inhibited the levels of ROS, NO, and Ca2+ in LPS-stimulated RAW264.7 cells. NZD reversed LPS-induced MMP (mitochondrial membrane potential) loss. Furthermore, NZD suppressed LPS-induced NF-B/p65 translocation from the cytoplasm into the nucleus[4]. SPE (Specneuzhenide) could inhibit the decrease of body weight compared with the model group, and trigger improvement in the renal index. High dose and low dose SPE could trigger a significant decrease in serum IL1β, IL-6 and TNF-α compared with the model group. SPE could attenuate the glomerular lesions in DN rats. SPE induced up-regulation of podocin and CD2AP. SPE showed protective effects on renal injury through attenuating the pathological injury and urine protein[5].
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