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SB-590885 {[allProObj[0].p_purity_real_show]}

货号:A720977

SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.

SB-590885 化学结构 CAS号:405554-55-4
SB-590885 化学结构
CAS号:405554-55-4
SB-590885 3D分子结构
CAS号:405554-55-4
SB-590885 化学结构 CAS号:405554-55-4
SB-590885 3D分子结构 CAS号:405554-55-4
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SB-590885 纯度/质量文件 产品仅供科研

货号:A720977 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 A-raf B-Raf C-Raf/Raf-1 Raf 其他靶点 纯度
Encorafenib 99%+
GDC-0879 ++++

B-Raf, IC50: 0.13 nM

99%+
SB-590885 ++++

B-Raf, Ki: 0.16 nM

99%+
RAF265 99%+
Dabrafenib ++++

B-Raf, IC50: 5.2 nM

B-Raf (V600E), IC50: 0.7 nM

+++

C-Raf, IC50: 6.3 nM

98%
Lifirafenib ++++

WT A-RAF, IC50: 1 nM

++

BRAF(V600E), IC50: 23 nM

BRAF WT, IC50: 32 nM

+++

C-RAF (Y340/341D), IC50: 7 nM

EGFR 98%
ZM 336372 +

C-Raf, IC50: 70 nM

99%+
NVP-BHG 712 +

C-Raf, IC50: 0.395 μM

99%+
CCT196969 +

BRAF, IC50: 0.1 μM

++

CRAF, IC50: 0.01 μM

Src 98%
Vemurafenib ++

B-Raf, IC50: 100 nM

B-Raf (V600E), IC50: 31 nM

+

C-Raf, IC50: 48 nM

98+%
PLX4720 ++

B-Raf, IC50: 160 nM

B-Raf (V600E), IC50: 13 nM

+++

C-Raf-1 (Y340D/Y341D), IC50: 6.7 nM

BRK 99+%
GW 5074 +++

C-Raf, IC50: 9 nM

99%+
Avutometinib +++

BRAF V600E, IC50: 8.2 nM

BRAF, IC50: 19 nM

+

CRAF, IC50: 56 nM

98%
LY3009120 ++++

BRAF(V600E), IC50: 5.8 nM

BRAF WT, IC50: 15 nM

++++

C-Raf, IC50: 4.3 nM

99%+
Agerafenib ++

B-Raf (V600E), Kd: 14 nM

B-Raf, Kd: 36 nM

+

C-Raf, Kd: 39 nM

RET 99%+
TAK-632 +++

B-Raf, IC50: 8.3 nM

++++

C-Raf, IC50: 1.4 nM

99%+
AZ 628 +

B-Raf, IC50: 105 nM

B-Raf (V600E), IC50: 34 nM

++

C-Raf-1, IC50: 29 nM

99%
PLX7904 98+%
Sorafenib ++

B-Raf, IC50: 22 nM

B-Raf (V599E), IC50: 38 nM

++++

Raf-1, IC50: 6 nM

++++

Raf-1, IC50: 6 nM

99%
Tovorafenib 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

SB-590885 生物活性

靶点
  • B-Raf

    B-Raf, Ki:0.16 nM

描述 The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Among them, B-RAF is the most frequently mutated protein kinase in human cancers. SB-590885 is a selective Raf kinase inhibitor with Kiapp value of 0.16nM for B-Raf (measured by kinase activity), 11-fold greater selectivity over c-Raf (Kiapp=1.72nM), with little inhibition to other human kinases. Treatment with SB-590885, 2μM for 1h, inhibited ERK phosphorylation in Colo205 and HT29 cell lines, as well as potently and preferentially inhibited ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Prolonged exposure to SB-590885, at dose ranging 0.1-10μM for 72h, inhibited cellular transformation and proliferation in three-dimensional culture. Daily administration of SB-590885 at dose of 50m/kg, i.p., decreased tumorigenesis in murine xenografts established from mutant B-Raf-expressing A375P melanoma cells[1].
作用机制 SB-590885 occupies the ATP-binding pocket of B-Raf and stabilizes the oncogenic B-Raf kinase domain in an active configuration.[1]

SB-590885 动物研究

Dose Nude Mice: 50 mg/kg[1] (i.p.)
Administration i.p.

SB-590885 参考文献

[1]King AJ, Patrick DR, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1;66(23):11100-5.

SB-590885 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.02mL

2.20mL

1.10mL

22.05mL

4.41mL

2.20mL

SB-590885 技术信息

CAS号405554-55-4
分子式C27H27N5O2
分子量 453.536
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 9 mg/mL(19.84 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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