AZ 628 | Apoptosis Inducer | AmBeed-信号通路专用抑制剂

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AZ 628 99%

货号：A552174

AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

AZ 628 化学结构
CAS号：878739-06-1

AZ 628 3D分子结构
CAS号：878739-06-1

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AZ 628 纯度/质量文件产品仅供科研

货号：A552174 标准纯度： 99% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

Raf 亚型比较

产品名称	A-raf ↓ ↑	B-Raf ↓ ↑	C-Raf/Raf-1 ↓ ↑	Raf ↓ ↑	其他靶点	纯度
Encorafenib		✔				99%+
GDC-0879		++++ B-Raf, IC50: 0.13 nM				99%+
SB-590885		++++ B-Raf, Ki: 0.16 nM				99%+
RAF265						99%+
Dabrafenib		++++ B-Raf, IC50: 5.2 nM B-Raf (V600E), IC50: 0.7 nM	+++ C-Raf, IC50: 6.3 nM			98%
Lifirafenib	++++ WT A-RAF, IC50: 1 nM	++ BRAF(V600E), IC50: 23 nM BRAF WT, IC50: 32 nM	+++ C-RAF (Y340/341D), IC50: 7 nM		EGFR	96%
ZM 336372			+ C-Raf, IC50: 70 nM			99%+
NVP-BHG 712			+ C-Raf, IC50: 0.395 μM			99%+
CCT196969		+ BRAF, IC50: 0.1 μM	++ CRAF, IC50: 0.01 μM		Src	98%
Vemurafenib		++ B-Raf, IC50: 100 nM B-Raf (V600E), IC50: 31 nM	+ C-Raf, IC50: 48 nM			98+%
PLX4720		++ B-Raf, IC50: 160 nM B-Raf (V600E), IC50: 13 nM	+++ C-Raf-1 (Y340D/Y341D), IC50: 6.7 nM		BRK	99+%
GW 5074			+++ C-Raf, IC50: 9 nM			99%+
Avutometinib		+++ BRAF, IC50: 19 nM BRAF V600E, IC50: 8.2 nM	+ CRAF, IC50: 56 nM			98%
LY3009120		++++ BRAF(V600E), IC50: 5.8 nM BRAF WT, IC50: 15 nM	++++ C-Raf, IC50: 4.3 nM			99%+
Agerafenib		++ B-Raf, Kd: 36 nM B-Raf (V600E), Kd: 14 nM	+ C-Raf, Kd: 39 nM		RET	99%+
TAK-632		+++ B-Raf, IC50: 8.3 nM	++++ C-Raf, IC50: 1.4 nM			99%+
AZ 628		+ B-Raf, IC50: 105 nM B-Raf (V600E), IC50: 34 nM	++ C-Raf-1, IC50: 29 nM			99%
PLX7904				✔		98+%
Sorafenib		++ B-Raf (V599E), IC50: 38 nM B-Raf, IC50: 22 nM	++++ Raf-1, IC50: 6 nM	++++ Raf-1, IC50: 6 nM		99%
Tovorafenib				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

AZ 628 生物活性

靶点	B-Raf B-Raf, IC50:105 nM B-Raf (V600E), IC50:34 nM C-Raf/Raf-1 C-Raf-1, IC50:29 nM
描述	AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

AZ 628 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
697 cell		Growth inhibition assay		Inhibition of human 697 cell growth in a cell viability assay, IC50=363.88 μM	SANGER
A101D cell		Growth inhibition assay		Inhibition of human A101D cell growth in a cell viability assay, IC50=5.82 nM	SANGER
A375 cells		Function assay	75 mins	Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human A375 cells after 75 mins, IC50=0.015 μM	23398453
ACN cell		Growth inhibition assay		Inhibition of human ACN cell growth in a cell viability assay, IC50=0.101 nM	SANGER

AZ 628 参考文献

[1]Montagut C, Sharma SV, et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008 Jun 15;68(12):4853-61.

[2]Khazak V, Astsaturov I, et al. Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets. 2007 Dec;11(12):1587-609. Review. Erratum in: Expert Opin Ther Targets. 2009 Sep;13(9):1135.

AZ 628 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.07mL

2.21mL

1.11mL

22.15mL

4.43mL

2.21mL

AZ 628 技术信息

CAS号	878739-06-1
分子式	C₂₇H₂₅N₅O₂
分子量	451.52

别名
运输	蓝冰

存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(110.74 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

697 cell	Growth inhibition assay		Inhibition of human 697 cell growth in a cell viability assay, IC50=363.88 μM	SANGER
A101D cell	Growth inhibition assay		Inhibition of human A101D cell growth in a cell viability assay, IC50=5.82 nM	SANGER
A375 cells	Function assay	75 mins	Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human A375 cells after 75 mins, IC50=0.015 μM	23398453
ACN cell	Growth inhibition assay		Inhibition of human ACN cell growth in a cell viability assay, IC50=0.101 nM	SANGER
BB49-HNC cell	Growth inhibition assay		Inhibition of human BB49-HNC cell growth in a cell viability assay, IC50=0.3518 μM	SANGER
Calu-6 cell	Growth inhibition assay		Inhibition of human Calu-6 cell growth in a cell viability assay, IC50=51.47 nM	SANGER
CGTH-W-1 cell	Growth inhibition assay		Inhibition of human CGTH-W-1 cell growth in a cell viability assay, IC50=121.3 nM	SANGER
COLO-829 cell	Growth inhibition assay		Inhibition of human COLO-829 cell growth in a cell viability assay, IC50=25.65 nM	SANGER
CP66-MEL cell	Growth inhibition assay		Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50=131.76 nM	SANGER
D-392MG cell	Growth inhibition assay		Inhibition of human D-392MG cell growth in a cell viability assay, IC50=0.35607 μM	SANGER
DU-4475 cell	Growth inhibition assay		Inhibition of human DU-4475 cell growth in a cell viability assay, IC50=10.23 nM	SANGER
EM-2 cell	Growth inhibition assay		Inhibition of human EM-2 cell growth in a cell viability assay, IC50=195.91 nM	SANGER
GDM-1 cell	Growth inhibition assay		Inhibition of human GDM-1 cell growth in a cell viability assay, IC50=0.22947 μM	SANGER
HCC2998 cell	Growth inhibition assay		Inhibition of human HCC2998 cell growth in a cell viability assay, IC50=0.22187 μM	SANGER
HL-60 cell	Growth inhibition assay		Inhibition of human HL-60 cell growth in a cell viability assay, IC50=154.41 nM	SANGER
HT-144 cell	Growth inhibition assay		Inhibition of human HT-144 cell growth in a cell viability assay, IC50=6.61 nM	SANGER
IST-MEL1 cell	Growth inhibition assay		Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50=204.13 nM	SANGER
K5 cell	Growth inhibition assay		Inhibition of human K5 cell growth in a cell viability assay, IC50=134.2 nM	SANGER
K-562 cell	Growth inhibition assay		Inhibition of human K-562 cell growth in a cell viability assay, IC50=0.66695 μM	SANGER
KMOE-2 cell	Growth inhibition assay		Inhibition of human KMOE-2 cell growth in a cell viability assay, IC50=115.88 nM	SANGER
KS-1 cell	Growth inhibition assay		Inhibition of human KS-1 cell growth in a cell viability assay, IC50=0.39337 μM	SANGER
LAMA-84 cell	Growth inhibition assay		Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=192.42 nM	SANGER
LAN-6 cell	Growth inhibition assay		Inhibition of human LAN-6 cell growth in a cell viability assay, IC50=0.68236 μM	SANGER
LB2518-MEL cell	Growth inhibition assay		Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50=4.76 nM	SANGER
LS-513 cell	Growth inhibition assay		Inhibition of human LS-513 cell growth in a cell viability assay, IC50=74.15 nM	SANGER
MEG-01 cell	Growth inhibition assay		Inhibition of human MEG-01 cell growth in a cell viability assay, IC50=0.376 μM	SANGER
ML-2 cell	Growth inhibition assay		Inhibition of human ML-2 cell growth in a cell viability assay, IC50=368.86 nM	SANGER
MMAC-SF cell	Growth inhibition assay		Inhibition of human MMAC-SF cell growth in a cell viability assay, IC50=40.07 nM	SANGER
MZ1-PC cell	Growth inhibition assay		Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50=0.27999 μM	SANGER
MZ7-mel cell	Growth inhibition assay		Inhibition of human MZ7-mel cell growth in a cell viability assay, IC50=117.27 nM	SANGER
NB14 cell	Growth inhibition assay		Inhibition of human NB14 cell growth in a cell viability assay, IC50=0.49331 μM	SANGER
NB69 cell	Growth inhibition assay		Inhibition of human NB69 cell growth in a cell viability assay, IC50=191.31 nM	SANGER
NCI-H1648 cell	Growth inhibition assay		Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50=0.67266 μM	SANGER
NCI-H747 cell	Growth inhibition assay		Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50=0.50637 μM	SANGER
NOS-1 cell	Growth inhibition assay		Inhibition of human NOS-1 cell growth in a cell viability assay, IC50=92.65 nM	SANGER
OCI-AML2 cell	Growth inhibition assay		Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50=0.017μM	SANGER
ONS-76 cell	Growth inhibition assay		Inhibition of human ONS-76 cell growth in a cell viability assay, IC50=166.62 nM	SANGER
PSN1 cell	Growth inhibition assay		Inhibition of human PSN1 cell growth in a cell viability assay, IC50=27.37 nM	SANGER
RKO cell	Growth inhibition assay		Inhibition of human RKO cell growth in a cell viability assay, IC50=37.67 nM	SANGER
SH-4 cell	Growth inhibition assay		Inhibition of human SH-4 cell growth in a cell viability assay, IC50=3.01 nM	SANGER
SIG-M5 cell	Growth inhibition assay		Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50=9.45 nM	SANGER
SK-MEL-1 cell	Growth inhibition assay		Inhibition of human SK-MEL-1 cell growth in a cell viability assay, IC50=0.38362 μM	SANGER
SW872 cell	Growth inhibition assay		Inhibition of human SW872 cell growth in a cell viability assay, IC50=96.48 nM	SANGER
UACC-257 cell	Growth inhibition assay		Inhibition of human UACC-257 cell growth in a cell viability assay, IC50=27.49 nM	SANGER

AZ 628 99%

AZ 628 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

AZ 628 质控信息

AZ 628 生物活性

AZ 628 细胞研究

AZ 628 参考文献

AZ 628 实验方案

AZ 628 技术信息

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B-Raf	B-Raf, IC50:105 nM B-Raf (V600E), IC50:34 nM
C-Raf/Raf-1	C-Raf-1, IC50:29 nM

AZ 628 99%

AZ 628 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

AZ 628 质控信息

AZ 628 生物活性

AZ 628 细胞研究

AZ 628 参考文献

AZ 628 实验方案

AZ 628 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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AZ 628 纯度/质量文件产品仅供科研