R406是一种口服可用的竞争性Syk/FLT3抑制剂,用于ATP结合,Ki为30 nM。它在体外强效抑制Syk激酶活性,IC50为41 nM,测量时ATP浓度与其Km值相对应。R406减少免疫复合物介导的炎症,还抑制Lyn(IC50 = 63 nM)和Lck(IC50 = 37 nM)。
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Syk ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRT062607 HCl |
++++
Syk, IC50: 1 nM |
99%+ | |||||||||||||||||
R406 |
++
Syk, IC50: 41 nM |
99%+ | |||||||||||||||||
Fostamatinib Disodium |
++
Syk, IC50: 41 nM |
99%+ | |||||||||||||||||
Piceatannol | ✔ | PKC | 99%+ | ||||||||||||||||
BAY 61-3606 2HCl |
+++
Syk, Ki: 7.5 nM |
99+% | |||||||||||||||||
Entospletinib |
+++
Syk, IC50: 7.7 nM |
99%+ | |||||||||||||||||
MNS |
+
Syk, IC50: 2.5 μM |
p97,Src | 99%+ | ||||||||||||||||
Fostamatinib |
++
Syk, IC50: 41 nM |
99%+ | |||||||||||||||||
RO9021 |
+++
Syk, IC50: 5.6 nM |
98% | |||||||||||||||||
TAK-659 HCl |
++++
Syk, IC50: 3.2 nM |
FLT3 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | FLT3 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R406 | ✔ | Syk | 99%+ | ||||||||||||||||
Go6976 | ✔ | 99%+ | |||||||||||||||||
Quizartinib |
+++
FLT3 (ITD), IC50: 1.1 nM FLT3 (WT), IC50: 4.2 nM |
99%+ | |||||||||||||||||
Gilteritinib |
++++
FLT3, IC50: 0.29 nM |
99%+ | |||||||||||||||||
Amuvatinib |
+
FLT3 (D835Y), IC50: 81 nM |
99%+ | |||||||||||||||||
Pacritinib |
++
FLT3 (D835Y), IC50: 6 nM FLT3, IC50: 22 nM |
97% | |||||||||||||||||
Dovitinib |
++++
FLT3, IC50: 1 nM |
c-Kit | 99%+ | ||||||||||||||||
Denfivontinib |
++++
FLT3 (D835Y), IC50: 0.4 nM FLT3, IC50: 0.4 nM |
RET | 99%+ | ||||||||||||||||
TAK-659 HCl |
++
FLT3, IC50: 4.6 nM |
Syk | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling. R406 inhibits the anti-IgE-induced production and release of LTC4 and cytokines and chemokines, including TNFα, IL-8, and GM-CSF. R406 inhibits phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 binds to the ATP binding pocket of Syk and inhibits its kinase activity as an ATP-competitive inhibitor with K of 30 nM. R406 blocks Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and Bcr-mediated activation of B lymphocytes. R406 significantly induces chronic lymphocytic leukemia (CLL) cell apoptosis in nurselike cells cocultures and blocks CCL3 and CCL4 secretion by CLL cells in response to B-cell antigen receptor (Bcr) triggering. R406 is a potent inhibitor of platelet signaling and functions initiated by FcγRIIA cross-linking by specific antibodies or by sera from HIT patients. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
AB5 | 0-2.5 μM | Apoptosis Assay | 48 h | induces apoptosis | 23398911 |
AB5 | 0-2.5 μM | Growth Inhibition Assay | 48 h | induces cell cycle arrest | 23398911 |
AMO-1 | 1 μM | Function Assay | 3 h | reduces migration | 26251761 |
CFSE-CD11b+ | 0.0625-1 μM | Growth Inhibition Assay | 8 d | blocks proliferation of GVHD-derived CD4+ T cells and CD11b+ cells | 24679982 |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.59mL 0.32mL 0.16mL |
7.95mL 1.59mL 0.80mL |
15.91mL 3.18mL 1.59mL |
CAS号 | 841290-81-1 |
分子式 | C28H29FN6O8S |
分子量 | 628.629 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 60 mg/mL(95.45 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 4% DMSO+4% Tween80+40% PEG300+water 1 mg/mL clear PO 0.5% CMC-Na 30 mg/mL suspension |