MNS is a tyrosine kinase inhibitor, inhibits Syk, Src,p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. It acts by inhibiting NLRP3ATPase activity and binding to the NACHT and LRR domains.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
MNS (NSC 170724), a beta-nitrostyrene derivative, functions as a potent tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. It completely inhibits platelet aggregation induced by U46619, ADP, arachidonic acid, collagen, and thrombin, with respective IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM. MNS also inhibits Src, Syk, and focal adhesion kinase (FAK) with IC50 values of 27.3, 2.8, and 97.6 μM, highlighting its potential as a therapeutic agent in conditions where platelet aggregation and tyrosine kinase activities are implicated[1].[2].
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HazMat Fee +
