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Paeonol

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Chemical Structure| 552-41-0 同义名 : 2-羟基-4-甲氧基苯乙酮 ;2'-Hydroxy-4'-methoxyacetophenone;Peonol;NSC 401442
CAS号 : 552-41-0
货号 : A173012
分子式 : C9H10O3
纯度 : 98%
分子量 : 166.174
MDL号 : MFCD00008730
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(240.71 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(6.02 mM)，配合低频超声助溶

无水乙醇: 45 mg/mL(270.8 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • MAO-B

    MAO-B, IC50:42.5 μM

  • MAO-A

    MAO-A, IC50:54.6 μM
描述 Monoamine oxidase (MAO) is an important enzyme in the metabolism of a wide range of endogenous monoamine neurotrasmitters such as noradrenaline, dopamine, and serotonin (5-HT), and also catalyzes as well the removal of exogenous amines. Paeonol, originated from the traditional Chinese medicine, is a naturally occuring MAO inhibitor with IC50 values of 54.6 μM and 42.5 μM for MAO-A and MAO-B, respectively[7]. Paeonol dose- and time- dependently induced not only antiproliferation activity and apoptosis but also autophagy via blocking the Akt/mTOR pathway in A2780 and SKOV3 cells. In addition, combination treatment with Paeonol and an autophagy inhibitor (3-methyladenine and hydroxychloroquine) showed significant synergetic effects on inhibiting cell viability and promoting apoptosis in vitro and in the A2780 xenograft model, without severe side effects[8]. Paeonol at 50 and 100μM prevented IL-1β-induced inflammatory response by inhibiting numerous factors of osteoarthritis(OA), including IL-6, TNF-a, NOX2, PTGS2, NUCB2/nesfatin-1, ICAM-1, VCAM-1, MMP-3/13, degradation of type II collagen, and NF-kB activation through the rescue of IkBa in human primary chondrocytes[9].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.02mL

1.20mL

0.60mL

30.09mL

6.02mL

3.01mL

60.18mL

12.04mL

6.02mL
参考文献

[1]Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5.

[2]Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003 Jul;139(6):1146-52.

[3]Lee H, Lee G, et al. Paeonol, a major compound of moutan cortex, attenuates Cisplatin-induced nephrotoxicity in mice. Evid Based Complement Alternat Med. 2013;2013:310989.

[4]Antidepressant-like Effect of Paeonol

[5]Tsai TH, Chou CJ, et al. Pharmacokinetics of paeonol after intravenous administration in rats. J Pharm Sci. 1994 Sep;83(9):1307-9.

[6]Ma L, Chuang CC, et al. Paeonol Protects Rat Heart by Improving Regional Blood Perfusion during No-Reflow. Front Physiol. 2016 Jul 21;7:298.

[7]Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5. doi: 10.1016/j.jep.2004.01.013. PMID: 15120460.

[8]Gao L, Wang Z, Lu D, Huang J, Liu J, Hong L. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death Dis. 2019 Aug 13;10(8):609. doi: 10.1038/s41419-019-1849-x. PMID: 31406198; PMCID: PMC6690917.

[9]Wang Q, Xu X, Kang Z, Zhang Z, Li Y. Paeonol prevents IL-1β-induced inflammatory response and degradation of type II collagen in human primary chondrocytes. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2139-2145. doi: 10.1080/21691401.2019.1613418. PMID: 31146598.