货号:A168725 同义名: 腺苷酸环化酶激活肽-38(抗原) / Pituitary Adenylate Cyclase Activating Polypeptide 38;PACAP 1-38
PACAP 1-38 is a potent PACAP receptor agonist with IC50s of 4 nM, 2 nM, and 1 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 respectively.
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产品名称 | AC ↓ ↑ | EPAC1 ↓ ↑ | EPAC2 ↓ ↑ | PACAP receptor ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
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Bithionol |
+
sAC, IC50: 4.0 μM |
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SQ22536 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ESI-09 |
++
EPAC1, IC50: 3.2 μM |
+++
EPAC2, IC50: 1.4 μM |
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HJC0350 |
+++
EPAC2, IC50: 0.3 μM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Pituitary adenylate cyclase-activating polypeptide (PACAP), belonging to the neuropeptide family, functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator and plays a critical role in neurogenesis[1]. As a fragment of pituitary adenylate cyclase activating polypeptide, PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively[2]. In vitro, PACAP (1-38) relaxed guinea-pig and rabbit tracheal smooth muscle precontracted by histamine and by acetylcholine[3]. In vivo, PACAP (1-38) dissolved in solutio ophthalmica cum benzalkonio led to significant protection in the retina in bilateral common carotid artery occlusion (BCCAO)-lesioned retinas; retinas treated with PACAP (1-38) eye drops had preserved structure compared to control retinas[4]. |
CAS号 | 137061-48-4 |
分子式 | N/A |
分子量 |
别名 | 腺苷酸环化酶激活肽-38(抗原) ;Pituitary Adenylate Cyclase Activating Polypeptide 38;PACAP 1-38 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
H2O: 100 mg/mL,配合低频超声助溶 |
动物实验配方 |