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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 /
cAMP
PACAP receptor
/ PACAP (1-38), human, ovine, rat

PACAP(1-38)游离态 /PACAP (1-38), human, ovine, rat {[allProObj[0].p_purity_real_show]}

货号：A168725 同义名： 腺苷酸环化酶激活肽-38(抗原) / Pituitary Adenylate Cyclase Activating Polypeptide 38;PACAP 1-38

PACAP 1-38 is a potent PACAP receptor agonist with IC50s of 4 nM, 2 nM, and 1 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 respectively.

PACAP (1-38), human, ovine, rat 化学结构 CAS号：137061-48-4
PACAP (1-38), human, ovine, rat 化学结构
CAS号：137061-48-4
PACAP (1-38), human, ovine, rat 3D分子结构
CAS号：137061-48-4
PACAP (1-38), human, ovine, rat 化学结构 CAS号：137061-48-4
PACAP (1-38), human, ovine, rat 3D分子结构 CAS号：137061-48-4
规格 价格 会员价 库存 数量
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PACAP (1-38), human, ovine, rat 纯度/质量文件 产品仅供科研

货号：A168725 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AC ↓ EPAC1 ↓ EPAC2 ↓ PACAP receptor ↓ 其他靶点 纯度
Bithionol +

sAC, IC50: 4.0 μM

 		98%
SQ22536 ✔ 99%+
ESI-09 ++

EPAC1, IC50: 3.2 μM

 		+++

EPAC2, IC50: 1.4 μM

 		98%
HJC0350 +++

EPAC2, IC50: 0.3 μM

 		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

PACAP (1-38), human, ovine, rat 生物活性

描述 Pituitary adenylate cyclase-activating polypeptide (PACAP), belonging to the neuropeptide family, functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator and plays a critical role in neurogenesis[1]. As a fragment of pituitary adenylate cyclase activating polypeptide, PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively[2]. In vitro, PACAP (1-38) relaxed guinea-pig and rabbit tracheal smooth muscle precontracted by histamine and by acetylcholine[3]. In vivo, PACAP (1-38) dissolved in solutio ophthalmica cum benzalkonio led to significant protection in the retina in bilateral common carotid artery occlusion (BCCAO)-lesioned retinas; retinas treated with PACAP (1-38) eye drops had preserved structure compared to control retinas[4].

PACAP (1-38), human, ovine, rat 参考文献

[1]Dautzenberg FM, et al. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. J Neuroendocrinol. 1999 Dec;11(12):941-9

[2]Gourlet P, et al. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur J Pharmacol. 1995 Dec 4;287(1):7-11

[3]Lindén A, et al. Inhibition of bronchoconstriction by pituitary adenylate cyclase activating polypeptide (PACAP 1-27) in guinea-pigs in vivo. Br J Pharmacol. 1995 Jul;115(6):913-6

[4]Werling D, et al. Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents. Int J Mol Sci. 2017 Mar 21;18(3):675

PACAP (1-38), human, ovine, rat 技术信息

CAS号137061-48-4
分子式N/A
分子量
别名 腺苷酸环化酶激活肽-38(抗原) ;Pituitary Adenylate Cyclase Activating Polypeptide 38;PACAP 1-38
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

H2O: 100 mg/mL，配合低频超声助溶
动物实验配方

Tags: PACAP (1-38), human, ovine, rat | 137061-48-4 | Pituitary Adenylate Cyclase Activating Polypeptide 38 | Pituitary Adenylate Cyclase Activating Polypeptide38 | Pituitary Adenylate Cyclase Activating Polypeptide-38 | PACAP Receptor | Pituitary adenylyl cyclase activating polypeptide receptor | GPCR/G Protein | PACAP Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | PACAP (1-38), human, ovine, rat 纯度/质量文件 | PACAP (1-38), human, ovine, rat 亚型比较 | PACAP (1-38), human, ovine, rat 生物活性 | PACAP (1-38), human, ovine, rat 参考文献 | PACAP (1-38), human, ovine, rat 技术信息

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