PACAP (1-38), human, ovine, rat

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Chemical Structure| 137061-48-4 同义名 : 腺苷酸环化酶激活肽-38(抗原) ;Pituitary Adenylate Cyclase Activating Polypeptide 38;PACAP 1-38
CAS号 : 137061-48-4
货号 : A168725
分子式 : N/A
纯度 : 98%
分子量 : 0
MDL号 : MFCD00081800
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL，配合低频超声助溶
动物实验配方：
生物活性
描述 Pituitary adenylate cyclase-activating polypeptide (PACAP), belonging to the neuropeptide family, functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator and plays a critical role in neurogenesis[1]. As a fragment of pituitary adenylate cyclase activating polypeptide, PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively[2]. In vitro, PACAP (1-38) relaxed guinea-pig and rabbit tracheal smooth muscle precontracted by histamine and by acetylcholine[3]. In vivo, PACAP (1-38) dissolved in solutio ophthalmica cum benzalkonio led to significant protection in the retina in bilateral common carotid artery occlusion (BCCAO)-lesioned retinas; retinas treated with PACAP (1-38) eye drops had preserved structure compared to control retinas[4].
参考文献

[1]Dautzenberg FM, et al. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. J Neuroendocrinol. 1999 Dec;11(12):941-9

[2]Gourlet P, et al. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur J Pharmacol. 1995 Dec 4;287(1):7-11

[3]Lindén A, et al. Inhibition of bronchoconstriction by pituitary adenylate cyclase activating polypeptide (PACAP 1-27) in guinea-pigs in vivo. Br J Pharmacol. 1995 Jul;115(6):913-6

[4]Werling D, et al. Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents. Int J Mol Sci. 2017 Mar 21;18(3):675