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Olverembatinib dimesylate
GZD824 Di甲磺酸盐 /Olverembatinib dimesylate
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货号：A423528
同义名：
GZD824 dimesylate;HQP1351 dimesylate
GZD824 dimesylate is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
Olverembatinib dimesylate 化学结构
CAS号：1421783-64-3
Olverembatinib dimesylate 3D分子结构
CAS号：1421783-64-3
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Olverembatinib dimesylate 纯度/质量文件 产品仅供科研
货号：A423528
标准纯度：
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Olverembatinib dimesylate 质控信息
- 转化生长因子-β 亚型比较
- Bcr-Abl 亚型比较
| NVP-BHG 712 |
+
|
|
|
99%+ |
| KW-2449 |
+++
Abl (T315I), IC50: 4 nM
Abl, IC50: 14 nM
|
|
FLT3
|
99%+ |
| Ponatinib |
++++
|
|
|
98% |
| AT9283 |
|
|
|
99%+ |
| Imatinib Mesylate |
+
|
|
c-Kit,PDGFR
|
99% |
| Danusertib |
++
|
|
RET
|
99%+ |
| Rebastinib |
++++
u-Abl1 (T315I), IC50: 5 nM
p-Abl1 (native), IC50: 0.75 nM
|
|
FLT3,Tie-2
|
99%+ |
| PP121 |
++
|
|
VEGFR,PDGFR
|
99%+ |
| GNF-7 |
+++
M351T, IC50: 133 nM
E255V, IC50: 122 nM
|
|
|
99%+ |
| Olverembatinib dimesylate |
++++
Abl, IC50: 0.34 nM
Abl (G250E), IC50: 0.35 nM
|
|
|
99% |
| Dasatinib monohydrate |
++++
|
|
Src
|
98% |
| Dasatinib |
++++
|
|
Src
|
98% |
| Bafetinib |
+++
|
|
|
98+% |
| GNF-2 |
|
+
Bcr-Abl (K562 cell line), IC50: 273 nM
Bcr-Abl (SUP-B15 cell line), IC50: 268 nM
|
|
98%+ |
| Degrasyn |
|
+
|
DUB
|
98+% |
| GNF-5 |
|
++
|
|
98% |
| Radotinib |
|
++
|
|
98+% |
| PD173955 |
|
|
Src
|
99%+ |
| Nilotinib |
|
++
|
|
98% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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Olverembatinib dimesylate 生物活性
| 靶点 |
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| 描述 |
GZD824 dimesylate is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. |
Olverembatinib dimesylate 参考文献
Olverembatinib dimesylate 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
|
1 mM
5 mM
10 mM
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1.38mL
0.28mL
0.14mL
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6.90mL
1.38mL
0.69mL
|
13.80mL
2.76mL
1.38mL
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Olverembatinib dimesylate 技术信息
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