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NIK SMI1

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Chemical Structure| 1660114-31-7 同义名 : -
CAS号 : 1660114-31-7
货号 : A1165846
分子式 : C20H19N3O4
纯度 : 99%+
分子量 : 365.383
MDL号 : MFCD31715434
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(328.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NIK SMI1 is a potent, selective NIK inhibitor that inhibits NIK-catalysed hydrolysis of ATP to ADP with an IC50 value of 0.23±0.17 nM. NIK SMI1 inhibits the expression of the firefly luciferase reporter gene, which is regulated by NIK SMI1-responsive elements, in HEK293 cells with an IC50 value of 34±6 nM. In line with the expectation that the inhibition of NIK NIK SMI1 inhibited nuclear translocation of p52(RelB) (IC50=70 nM). Consistent with the expectation of NIK inhibition, NIK SMI1 inhibited BAFF-induced B-cell (mouse) survival in vitro with an IC50 of 373±64 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.68mL

2.74mL

1.37mL

27.37mL

5.47mL

2.74mL
参考文献

[1]Blaquiere N, et al. Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase. J Med Chem. 2018 Aug 9;61(15):6801-6813.