NH125
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货号：A261079
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, also a potent histidine kinase inhibitor.
NH125 化学结构
NH125 3D分子结构
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NH125 纯度/质量文件 产品仅供科研
货号：A261079
标准纯度：
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NH125 质控信息
KN-62
+
98%
KN-93
++
98%
NH125
+++
eEF-2 kinase, IC50: 60 nM
99%+
STO-609
++
++++
98%
CID755673
+++
PKD1, IC50: 180 nM
PKD2, IC50: 227 nM
99%+
CRT0066101 2HCl
++++
PKD1, IC50: 1 nM
PKD2, IC50: 2 nM
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
NH125 生物活性
靶点
CaMKIII
eEF-2 kinase, IC50:60 nM
描述
H125 is a selective eEF2K inhibitor with IC50 value of 60nM in vitro . It blocked the phosphorylation of eEF-2 in intact C6 glioma cells at 1μM post 12h. It decreased the viability of 10 cancer cell lines from rat glioblastoma, human glioblastoma, human ovarian carcinoma, human cervical carcinoma, human prostate carcinoma, human ovarian carcinoma and human breast carcinoma with IC50 values ranging from 0.7 to 4.7μM[3] [4]
NH125 动物研究
Dose
Mice: 1 mg/kg[3] [4]
Administration
i.p., i.v.
NH125 参考文献
[1] Arora S, Yang JM, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9.
[2] Chen Z, Gopalakrishnan SM, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8.
[3] Arora S, Yang JM, Kinzy TG, Utsumi R, Okamoto T, Kitayama T, Ortiz PA, Hait WN. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9. PMID: 14583488.
[4] Chen Z, Gopalakrishnan SM, Bui MH, Soni NB, Warrior U, Johnson EF, Donnelly JB, Glaser KB. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-43958. doi: 10.1074/jbc.M111.301291. Epub 2011 Oct 21. PMID: 22020937; PMCID: PMC3243513.
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NH125 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.91mL
0.38mL
0.19mL
9.53mL
1.91mL
0.95mL
19.06mL
3.81mL
1.91mL
NH125 技术信息
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