CID755673是一种强效且选择性的细胞活性小分子抑制剂,针对 PKD(蛋白激酶 D)具有 IC50 值为 182 nM,且与 AKT、PLK1、CAK、CAMKIIα 和 PKC 亚型相比,选择性抑制 PKD1。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100μL*10mM(DMSO) | ¥109随货¥79 | 咨询 | |
250μL*10mM(DMSO) | ¥229随货¥169 | 咨询 | |
500μL*10mM(DMSO) | ¥299随货¥209 | 咨询 | |
10mM*1mL(DMSO) | ¥462 | 咨询 | |
1mg | ¥171 | 咨询 | |
5mg | ¥378 | 咨询 | |
10mg | ¥567 | 咨询 | |
25mg | ¥1312 | 咨询 | |
50mg | ¥1575 | 咨询 | |
100mg | ¥2835 | 咨询 |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
靶点 |
|
描述 | CID755673 is the first potent and selective cell-active small molecule PKD inhibitor with IC50 value of 182nM for inhibition of PKD1 enzyme activity. Pretreatment with CID755673 for 45min at 50μM blocked PMA-induced endogenous PKD1 activation shown by phosphorylation at Ser742 and Ser916 in LNCaP cells. Further study showed that CID755673 inhibited the known biological actions of PKD1 including PMA- induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation. Significant inhibition of prostate cancer cell proliferation, cell migration, and invasion could be observed post treatment with 25μM CID755673. Treatment with CID755673 at concentration ranging in 10-200μM indeed resulted in a significant dose-dependent reduction of NK cell degranulation markers and cytokine release in freshly isolated Peripheral blood mononuclear cell populations from healthy blood donors. |
Dose | Rat: 15 mg/kg[3] (i.p.); 10 mg/kg (i.v.) Mice: 1 mg/kg, 10 mg/kg[4] (i.p.) |
Administration | i.p., i.v. |
计算器 | ||||
存储液制备 | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 4.60mL 0.92mL 0.46mL | 23.02mL 4.60mL 2.30mL | 46.04mL 9.21mL 4.60mL |
CAS号 | 521937-07-5 |
分子式 | C12H11NO3 |
分子量 | 217.221 |
别名 | |
运输 | 蓝冰 |
存储条件 | In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,2-8°C |
溶解方案 | DMSO: 105 mg/mL(483.38 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
|
动物实验配方 | 2%DMSO+30%peg300+2%t-80+ddawater 6 mg/mL |