Minaprine dihydrochloride | MAO | AmBeed-信号通路专用抑制剂

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米那卜林二盐酸盐 /Minaprine dihydrochloride {[allProObj[0].p_purity_real_show]}

货号：A458274

Minaprine dihydrochloride是一种可逆的单胺氧化酶A（MAO-A）抑制剂，亦可轻微抑制乙酰胆碱酯酶，并作为抗抑郁药治疗抑郁症。

Minaprine dihydrochloride 化学结构
CAS号：25953-17-7

Minaprine dihydrochloride 3D分子结构
CAS号：25953-17-7

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Minaprine dihydrochloride 纯度/质量文件产品仅供科研

货号：A458274 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

MAO 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			98%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	97%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	98%
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	98%
Tranylcypromine hydrochloride		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	97%
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Minaprine dihydrochloride 生物活性

描述	Minaprine dihydrochloride is a reversible inhibitor of MAO-A, also weakly inhibits acetylcholinesterase and is an antidepressant for treatment of depression.

Minaprine dihydrochloride 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00940823	-		Completed	-	-
NCT03499964	Urethral Stricture	Not Applicable	Recruiting	November 2024	United States, Arkansas ... 展开 >> Arkansas Urology Recruiting Little Rock, Arkansas, United States, 72211 Contact: Katie O'Brien Principal Investigator: Richard D'Anna, MD Sub-Investigator: Keith Mooney, MD Sub-Investigator: Edwin Diaz, MD Sub-Investigator: Jeffrey Marotte, MD Sub-Investigator: Megan Thomas, APRN United States, Colorado Urology Associates, P.C. Recruiting Englewood, Colorado, United States, 80113 Contact: Lenden Neeper Contact: Michelle Lexin Principal Investigator: Barrett Cowan, MD United States, Florida Advanced Urology Institute Recruiting Daytona Beach, Florida, United States, 32114 Contact: Jonelle Horsley Principal Investigator: Jeffrey Dann, MD United States, Maryland Chesapeake Urology Recruiting Hanover, Maryland, United States, 21076 Contact: Wendy Paxton Principal Investigator: Kaiser Robertson, MD Sub-Investigator: Robert Goldfarb, MD Chesapeake Urology Research Recruiting Towson, Maryland, United States, 21204 Contact: Jacqueline Burmer Principal Investigator: Richard Levin, MD Sub-Investigator: Ronald Tutrone, MD United States, Minnesota University of Minnesota Department of Urology Not yet recruiting Minneapolis, Minnesota, United States, 55445 Contact: Bethany Marlette Principal Investigator: Sean Elliott, MD United States, New Jersey Delaware Valley Urology Recruiting Voorhees, New Jersey, United States, 08043 Contact: Brianna Florentine Principal Investigator: David Sussman, DO United States, New York Western New York Urology Associates Recruiting Cheektowaga, New York, United States, 14225 Contact: Margaret Scott Contact: Thomasina Smith Principal Investigator: Kent Chevli, MD Sub-Investigator: Peter Walter, MD Columbia University Medical Center/New York-Presbyterian Hospital Not yet recruiting New York, New York, United States, 10032 Contact: Debduth Pijush Principal Investigator: Steven Brandes, MD Iris Cantor Men's Health Center Recruiting New York, New York, United States, 10065 Contact: Dominique Thomas Principal Investigator: Alexis Te, MD United States, Oregon Oregon Urology Institute Recruiting Springfield, Oregon, United States, 97477 Contact: Danna Cardenas Principal Investigator: David DiMarco, MD Sub-Investigator: Brian Mehlaff, MD United States, South Carolina Carolina Urology Partners Recruiting West Columbia, South Carolina, United States, 29169 Contact: Pam Tims Contact: Kristin Kennedy Principal Investigator: Brian Willard, MD Sub-Investigator: David Lamb, MD Sub-Investigator: Keith Brightbill, MD Sub-Investigator: Griffin Morrisson, MD United States, Texas Urology San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Jeannette Cruz Principal Investigator: Christopher Cantrill, MD Sub-Investigator: Daniel Saltzstein, MD Sub-Investigator: Clayton Hudnall, MD Sub-Investigator: Davie Talley, MD United States, Virginia Urology of Virginia Recruiting Virginia Beach, Virginia, United States, 23462 Contact: Daniel Bekong Principal Investigator: Ramon Virasoro, MD Sub-Investigator: Jessica DeLong, MD Sub-Investigator: Jeremy Tonkin, MD Sub-Investigator: Kurt McCammon, MD United States, Washington University of Washington Harborview Medical Center Recruiting Seattle, Washington, United States, 98104 Contact: Michael Donahue Principal Investigator: Judith Hagedorn, MD Sub-Investigator: Neils Johnsen, MD 收起 <<
NCT00852852	Cancer	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98115 收起 <<

Minaprine dihydrochloride 参考文献

[1]Contreras JM, Rival YM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.

Minaprine dihydrochloride 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.47mL

2.69mL

1.35mL

26.93mL

5.39mL

2.69mL

Minaprine dihydrochloride 技术信息

CAS号	25953-17-7
分子式	C₁₇H₂₄Cl₂N₄O
分子量	371.305

别名
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解方案

细胞实验：

DMSO: 105 mg/mL(282.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(269.32 mM)，配合低频超声助溶

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00940823	-		Completed	-	-
NCT03499964	Urethral Stricture	Not Applicable	Recruiting	November 2024	United States, Arkansas ... 展开 >> Arkansas Urology Recruiting Little Rock, Arkansas, United States, 72211 Contact: Katie O'Brien Principal Investigator: Richard D'Anna, MD Sub-Investigator: Keith Mooney, MD Sub-Investigator: Edwin Diaz, MD Sub-Investigator: Jeffrey Marotte, MD Sub-Investigator: Megan Thomas, APRN United States, Colorado Urology Associates, P.C. Recruiting Englewood, Colorado, United States, 80113 Contact: Lenden Neeper Contact: Michelle Lexin Principal Investigator: Barrett Cowan, MD United States, Florida Advanced Urology Institute Recruiting Daytona Beach, Florida, United States, 32114 Contact: Jonelle Horsley Principal Investigator: Jeffrey Dann, MD United States, Maryland Chesapeake Urology Recruiting Hanover, Maryland, United States, 21076 Contact: Wendy Paxton Principal Investigator: Kaiser Robertson, MD Sub-Investigator: Robert Goldfarb, MD Chesapeake Urology Research Recruiting Towson, Maryland, United States, 21204 Contact: Jacqueline Burmer Principal Investigator: Richard Levin, MD Sub-Investigator: Ronald Tutrone, MD United States, Minnesota University of Minnesota Department of Urology Not yet recruiting Minneapolis, Minnesota, United States, 55445 Contact: Bethany Marlette Principal Investigator: Sean Elliott, MD United States, New Jersey Delaware Valley Urology Recruiting Voorhees, New Jersey, United States, 08043 Contact: Brianna Florentine Principal Investigator: David Sussman, DO United States, New York Western New York Urology Associates Recruiting Cheektowaga, New York, United States, 14225 Contact: Margaret Scott Contact: Thomasina Smith Principal Investigator: Kent Chevli, MD Sub-Investigator: Peter Walter, MD Columbia University Medical Center/New York-Presbyterian Hospital Not yet recruiting New York, New York, United States, 10032 Contact: Debduth Pijush Principal Investigator: Steven Brandes, MD Iris Cantor Men's Health Center Recruiting New York, New York, United States, 10065 Contact: Dominique Thomas Principal Investigator: Alexis Te, MD United States, Oregon Oregon Urology Institute Recruiting Springfield, Oregon, United States, 97477 Contact: Danna Cardenas Principal Investigator: David DiMarco, MD Sub-Investigator: Brian Mehlaff, MD United States, South Carolina Carolina Urology Partners Recruiting West Columbia, South Carolina, United States, 29169 Contact: Pam Tims Contact: Kristin Kennedy Principal Investigator: Brian Willard, MD Sub-Investigator: David Lamb, MD Sub-Investigator: Keith Brightbill, MD Sub-Investigator: Griffin Morrisson, MD United States, Texas Urology San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Jeannette Cruz Principal Investigator: Christopher Cantrill, MD Sub-Investigator: Daniel Saltzstein, MD Sub-Investigator: Clayton Hudnall, MD Sub-Investigator: Davie Talley, MD United States, Virginia Urology of Virginia Recruiting Virginia Beach, Virginia, United States, 23462 Contact: Daniel Bekong Principal Investigator: Ramon Virasoro, MD Sub-Investigator: Jessica DeLong, MD Sub-Investigator: Jeremy Tonkin, MD Sub-Investigator: Kurt McCammon, MD United States, Washington University of Washington Harborview Medical Center Recruiting Seattle, Washington, United States, 98104 Contact: Michael Donahue Principal Investigator: Judith Hagedorn, MD Sub-Investigator: Neils Johnsen, MD 收起 <<
NCT00852852	Cancer	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98115 收起 <<
NCT00940823	Glaucoma	Not Applicable	Completed	-	United States, Indiana ... 展开 >> Eugene and Marilyn Glick Eye Institute Indianapolis, Indiana, United States, 46202 United States, Tennessee Vanderbilt Eye Institute Nashville, Tennessee, United States, 37232 United States, Wisconsin Drs. Massaro and Kalenak Milwaukee, Wisconsin, United States, 53226 Canada, Ontario Credit ValleyEC Toronto, Ontario, Canada, L5L 1W8 Canada, Quebec Montreal Glaucoma Institute Montreal, Quebec, Canada, H1V 1G5 Chile Clinic of Las Condes Santiago, Chile 收起 <<
NCT02457468	-		Recruiting	June 2023	-
NCT03265210	Chronic Pain ... 展开 >>Depression 收起 <<	Not Applicable	Recruiting	September 1, 2019	United States, New York ... 展开 >> Weill Cornell Internal Medicine Associates Recruiting New York, New York, United States, 10021 Contact: Joanna Pantelides 914-682-9100 ext 2903 jop2285@med.cornell.edu Iris Cantor Men's & Women's Health Centers Recruiting New York, New York, United States, 10065 Contact: Joanna Pantelides 914-682-9100 ext 2903 jop2285@med.cornell.edu 收起 <<
NCT02522611	Intractable Pain ... 展开 >> Palliative Care Neoplasm Metastasis Questionnaires &Amp; Surveys 收起 <<	Phase 1 Phase 2	Recruiting	February 1, 2019	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
NCT00692653	Prostate Cancer	Not Applicable	Completed	-	United States, Georgia ... 展开 >> VA Medical Center / Medical College of Georgia Augusta, Georgia, United States, 30904 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 United States, Texas University of Texas Health Sciences Center at San Antonio San Antonio, Texas, United States, 78229 United States, Washington Seattle Prostate Institute Seattle, Washington, United States, 98104 Veterans Administration Puget Sound Health Care System Seattle, Washington, United States, 98108 University of Washington Medical Center Seattle, Washington, United States, 98195 收起 <<
NCT00345046	Glaucoma Cata... 展开 >>ract 收起 <<	Phase 4	Completed	-	United States, Indiana ... 展开 >> IU Eye at Carmel Indianapolis, Indiana, United States, 46290 收起 <<
NCT00345046	-		Completed	-	-
NCT00352807	Cataract	Not Applicable	Completed	-	United States, Indiana ... 展开 >> University Hospital Indianapolis, Indiana, United States, 46202 Veterans Affairs Medical Center Indianapolis, Indiana, United States, 46202 Wishard Memorial Hospital Indianapolis, Indiana, United States, 46202 Iu Eye at Carmel Indianapolis, Indiana, United States, 46290 收起 <<
NCT00355446	Cataract	Phase 4	Completed	-	United States, Indiana ... 展开 >> University Hospital Indianapolis, Indiana, United States, 46202 Veterans Affairs Medical Center Indianapolis, Indiana, United States, 46202 Wishard Memorial Hospital Indianapolis, Indiana, United States, 46202 IU Eye at Carmel Indianapolis, Indiana, United States, 46290 收起 <<
NCT00603304	Urological	Phase 3	Completed	-	United States, California ... 展开 >> Kaiser Permanente Division of Research Oakland, California, United States, 94612 United States, Colorado University of Colorado Aurora, Colorado, United States, 80045 United States, Connecticut Yale University New Haven, Connecticut, United States, 06519 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, New York New York University New York, New York, United States, 10006 Cornell University New York, New York, United States, 10021 United States, Texas University of Texas - Southwestern Medical Center Dallas, Texas, United States, 21201 Canada, Ontario Queen's University Kingston, Ontario, Canada, K7L2V7 收起 <<
NCT00392275	Cataract	Phase 4	Completed	-	United States, Indiana ... 展开 >> Indiana University Hospital Indianapolis, Indiana, United States, 46202 Richard L Rodeboush VA Medical Center Indianapolis, Indiana, United States, 46202 Wishard Memorial Hospital Indianapolis, Indiana, United States, 46202 收起 <<
NCT00603304	-		Completed	-	-
NCT00164190	Myocardial Infarction	Not Applicable	Completed	-	Canada, Ontario ... 展开 >> Southlake Regional Health Centre Newmarket, Ontario, Canada, L3Y 2R2 收起 <<
NCT00597181	Glaucoma	Phase 4	Terminated(Patient population ... 展开 >>limited) 收起 <<	-	United States, Indiana ... 展开 >> IU Eye at Carmel Indianapolis, Indiana, United States, 46290 收起 <<
NCT01142583	-		Completed	-	-
NCT00346489	Glaucoma	Phase 4	Completed	-	United States, Indiana ... 展开 >> University Hospital and Outpatient Center Indianapolis, Indiana, United States, 46202 IU Eye at Carmel Indianapolis, Indiana, United States, 46290 收起 <<

米那卜林二盐酸盐 /Minaprine dihydrochloride {[allProObj[0].p_purity_real_show]}

Minaprine dihydrochloride 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Minaprine dihydrochloride 质控信息

Minaprine dihydrochloride 生物活性

Minaprine dihydrochloride 临床研究

Minaprine dihydrochloride 参考文献

Minaprine dihydrochloride 实验方案

Minaprine dihydrochloride 技术信息

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米那卜林二盐酸盐 /Minaprine dihydrochloride {[allProObj[0].p_purity_real_show]}

Minaprine dihydrochloride 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Minaprine dihydrochloride 质控信息

Minaprine dihydrochloride 生物活性

Minaprine dihydrochloride 临床研究

Minaprine dihydrochloride 参考文献

Minaprine dihydrochloride 实验方案

Minaprine dihydrochloride 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Minaprine dihydrochloride 纯度/质量文件产品仅供科研