货号:A160451 同义名: AHR 85;NSC 170960
Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.
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产品名称 | Carbonic Anhydrase ↓ ↑ | Carbonic Anhydrase I ↓ ↑ | Carbonic Anhydrase II ↓ ↑ | Carbonic Anhydrase IV ↓ ↑ | Carbonic Anhydrase IX ↓ ↑ | Carbonic Anhydrase XII ↓ ↑ | 其他靶点 | 纯度 | |||||||||||
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Topiramate | ✔ | Calcium Channel | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Dichlorphenamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Mafenide Acetate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Benzenesulphonamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dorzolamide HCl |
+
Carbonic anhydrase I, Ki: 6000 nM |
++++
Carbonic anhydrase II, Ki: 1.9 nM |
+++
Carbonic anhydrase IV, Ki: 31 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Methazolamide |
++
hCAI, Ki: 50 nM |
+++
hCAII, Ki: 14 nM |
++
bCAIV, Ki: 36 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Tioxolone |
+
CAI, Ki: 91 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
U-104 |
++
CAIX, Ki: 45.1 nM |
++++
CAXII, Ki: 4.5 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury[3]. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. Absorption and elimination of methocarbamol is similar between normal subjects and patients undergoing maintenance haemodialysis[4]. Patients who were treated with methocarbamol showed a significant decrease in the frequency and duration of cramps. Also, the pain score improved significantly. Methocarbamol seems to be a promising safe and well-tolerated medication, and plays a role in the treatment of muscle cramps in patients with liver cirrhosis[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00770497 | Inflammation ... 展开 >>Hypertension 收起 << | Phase 2 | Completed | - | Germany ... 展开 >> Deggingen, Baden-Württemberg, Germany Rottweil, Baden-Württemberg, Germany Spaichingen, Baden-Württemberg, Germany Weilersbach, Bayern, Germany Hannover, Niedersachsen, Germany Essen, Nordrhein-Westfalen, Germany Köln, Nordrhein-Westfalen, Germany Werne, Nordrhein-Westfalen, Germany Mainz, Rheinland-Pfalz, Germany Schauenburg, Rheinland-Pfalz, Germany Dresden, Sachsen, Germany Blankenhain, Thüringen, Germany Berlin, Germany 收起 << |
NCT02707094 | Chronic Low Back Pain | Not Applicable | Completed | - | United States, Texas ... 展开 >> Brooke Army Medical Center Fort Sam Houston, Texas, United States, 78234 收起 << |
NCT02669875 | Liver Cirrhosis ... 展开 >> Hypertension, Portal 收起 << | Phase 2 | Completed | - | United Kingdom ... 展开 >> Liver Unit, Royal Infirmary of Edinburgh Edinburgh, United Kingdom, EH164TJ 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.15mL 0.83mL 0.41mL |
20.73mL 4.15mL 2.07mL |
41.45mL 8.29mL 4.15mL |
CAS号 | 532-03-6 |
分子式 | C11H15NO5 |
分子量 | 241.24 |
别名 | AHR 85;NSC 170960 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(435.25 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 4 mg/mL(16.58 mM),配合低频超声助溶 |
动物实验配方 |