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/ Methocarbamol

美索巴莫 /Methocarbamol {[allProObj[0].p_purity_real_show]}

货号：A160451 同义名： AHR 85;NSC 170960

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.

Methocarbamol 化学结构 CAS号：532-03-6
Methocarbamol 化学结构
CAS号：532-03-6
Methocarbamol 3D分子结构
CAS号：532-03-6
Methocarbamol 化学结构 CAS号：532-03-6
Methocarbamol 3D分子结构 CAS号：532-03-6
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Methocarbamol 纯度/质量文件 产品仅供科研

货号：A160451 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Carbonic Anhydrase ↓ Carbonic Anhydrase I ↓ Carbonic Anhydrase II ↓ Carbonic Anhydrase IV ↓ Carbonic Anhydrase IX ↓ Carbonic Anhydrase XII ↓ 其他靶点 纯度
Topiramate ✔ Calcium Channel 98%
Dichlorphenamide ✔ 98%
Mafenide Acetate ✔ 98%
Benzenesulphonamide ✔ 98%
Dorzolamide HCl +

Carbonic anhydrase I, Ki: 6000 nM

 		++++

Carbonic anhydrase II, Ki: 1.9 nM

 		+++

Carbonic anhydrase IV, Ki: 31 nM

 		98%
Methazolamide ++

hCAI, Ki: 50 nM

 		+++

hCAII, Ki: 14 nM

 		++

bCAIV, Ki: 36 nM

 		98%
Tioxolone +

CAI, Ki: 91 nM

 		98%
U-104 ++

CAIX, Ki: 45.1 nM

 		++++

CAXII, Ki: 4.5 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Methocarbamol 生物活性

描述 Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury[3]. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. Absorption and elimination of methocarbamol is similar between normal subjects and patients undergoing maintenance haemodialysis[4]. Patients who were treated with methocarbamol showed a significant decrease in the frequency and duration of cramps. Also, the pain score improved significantly. Methocarbamol seems to be a promising safe and well-tolerated medication, and plays a role in the treatment of muscle cramps in patients with liver cirrhosis[5].

Methocarbamol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00770497 Inflammation ... 展开 >>Hypertension 收起 << Phase 2 Completed - Germany ... 展开 >> Deggingen, Baden-Württemberg, Germany Rottweil, Baden-Württemberg, Germany Spaichingen, Baden-Württemberg, Germany Weilersbach, Bayern, Germany Hannover, Niedersachsen, Germany Essen, Nordrhein-Westfalen, Germany Köln, Nordrhein-Westfalen, Germany Werne, Nordrhein-Westfalen, Germany Mainz, Rheinland-Pfalz, Germany Schauenburg, Rheinland-Pfalz, Germany Dresden, Sachsen, Germany Blankenhain, Thüringen, Germany Berlin, Germany 收起 <<
NCT02707094 Chronic Low Back Pain Not Applicable Completed - United States, Texas ... 展开 >> Brooke Army Medical Center Fort Sam Houston, Texas, United States, 78234 收起 <<
NCT02669875 Liver Cirrhosis ... 展开 >> Hypertension, Portal 收起 << Phase 2 Completed - United Kingdom ... 展开 >> Liver Unit, Royal Infirmary of Edinburgh Edinburgh, United Kingdom, EH164TJ 收起 <<

Methocarbamol 参考文献

[1]Rumpler MJ, Colahan P, Sams RA. The pharmacokinetics of methocarbamol and guaifenesin after single intravenous and multiple-dose oral administration of methocarbamol in the horse. J Vet Pharmacol Ther. 2014 Feb;37(1):25-34.

[2]Kuo K, Odunayo A. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. J Vet Emerg Crit Care (San Antonio). 2013 Jul-Aug;23(4):436-41.

[3]Methocarbamol. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 30, 2017

[4]Sica DA, Comstock TJ, Davis J, et al. Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-194

[5]Abd-Elsalam S, Arafa M, Elkadeem M, et al. Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients. Eur J Gastroenterol Hepatol. 2019;31(4):499-502

Methocarbamol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.15mL

0.83mL

0.41mL

20.73mL

4.15mL

2.07mL

41.45mL

8.29mL

4.15mL

Methocarbamol 技术信息

CAS号532-03-6
分子式C11H15NO5
分子量 241.24
别名 AHR 85;NSC 170960
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 105 mg/mL(435.25 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 4 mg/mL(16.58 mM)，配合低频超声助溶
动物实验配方

Tags: Methocarbamol | 532-03-6 | Membrane Transporter/Ion Channel | Sodium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Methocarbamol 纯度/质量文件 | Methocarbamol 亚型比较 | Methocarbamol 生物活性 | Methocarbamol 临床数据 | Methocarbamol 参考文献 | Methocarbamol 实验方案 | Methocarbamol 技术信息

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