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盐酸磺胺米隆 /Mafenide HCl {[allProObj[0].p_purity_real_show]}

货号:A275314 同义名: 4-氨甲基苯磺酰胺盐酸盐 / Mafenide hydrochloride;4-Aminomethylbenzenesulfonamide hydrochloride Ambeed 开学季,买赠积分,赢豪礼

Mafenide HCl is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as a topical anti-bacterial agent, especially in burn therapy.

Mafenide HCl 化学结构 CAS号:138-37-4
Mafenide HCl 化学结构
CAS号:138-37-4
Mafenide HCl 3D分子结构
CAS号:138-37-4
Mafenide HCl 化学结构 CAS号:138-37-4
Mafenide HCl 3D分子结构 CAS号:138-37-4
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Mafenide HCl 纯度/质量文件 产品仅供科研

货号:A275314 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 Carbonic Anhydrase Carbonic Anhydrase I Carbonic Anhydrase II Carbonic Anhydrase IV Carbonic Anhydrase IX Carbonic Anhydrase XII 其他靶点 纯度
Topiramate Calcium Channel {[allProObj[0].p_purity_real_show]}
Dichlorphenamide {[allProObj[0].p_purity_real_show]}
Mafenide Acetate {[allProObj[0].p_purity_real_show]}
Benzenesulphonamide {[allProObj[0].p_purity_real_show]}
Dorzolamide HCl +

Carbonic anhydrase I, Ki: 6000 nM

++++

Carbonic anhydrase II, Ki: 1.9 nM

+++

Carbonic anhydrase IV, Ki: 31 nM

{[allProObj[0].p_purity_real_show]}
Methazolamide ++

hCAI, Ki: 50 nM

+++

hCAII, Ki: 14 nM

++

bCAIV, Ki: 36 nM

{[allProObj[0].p_purity_real_show]}
Tioxolone +

CAI, Ki: 91 nM

{[allProObj[0].p_purity_real_show]}
U-104 ++

CAIX, Ki: 45.1 nM

++++

CAXII, Ki: 4.5 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Mafenide HCl 生物活性

描述 Mafenide hydrochloride is a sulfonamide-type medication used as an antibiotic. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns[3]. The activity of 2.5% mafenide hydrochloride solution was equal to that of 4% mafenide HCl and could be used clinically with significant savings and perhaps, fewer side effects[4]. Survival time was lengthened by the application of some topical antibacterial agents, but actual recovery was achieved only with topical mafenide hydrochloride solution aqueous spray, which resulted in negative clostridium. Mafenide hydrochloride solution spray has been used successfully in treatment of patients with severe by contaminated wounds and deep burns[1].

Mafenide HCl 参考文献

[1]Mendelson JA. Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue. Prehosp Disaster Med. 2001;16(3):172–174

[2]Mendelson JA. The management of burns under conditions of limited resources using topical aqueous sulfamylon (mafenide) hydrochloride spray. J Burn Care Rehabil. 1997 May-Jun;18(3):238-44.

[3]Haik J, Ashkenazy O, Sinai S, et al. Burn care standards in Israel: lack of consensus. Burns. 2005;31(7):845–849

[4]Holder IA. Wet disc testing of mafenide hydrochloride, chlorhexidine gluconate, and triple antibiotic solution against bacteria isolated from burn wounds. J Burn Care Rehabil. 1990;11(4):301–304

Mafenide HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.49mL

0.90mL

0.45mL

22.45mL

4.49mL

2.25mL

44.91mL

8.98mL

4.49mL

Mafenide HCl 技术信息

CAS号138-37-4
分子式C7H11ClN2O2S
分子量 222.692
别名 4-氨甲基苯磺酰胺盐酸盐 ;Mafenide hydrochloride;4-Aminomethylbenzenesulfonamide hydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 120 mg/mL(538.86 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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