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毛花甙丙 /Lanatoside C {[allProObj[0].p_purity_real_show]}

货号:A147174 同义名: 毛花苷C Ambeed 开学季,买赠积分,赢豪礼

Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells.

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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Lanatoside C 化学结构 CAS号:17575-22-3
Lanatoside C 化学结构
CAS号:17575-22-3
Lanatoside C 3D分子结构
CAS号:17575-22-3
Lanatoside C 化学结构 CAS号:17575-22-3
Lanatoside C 3D分子结构 CAS号:17575-22-3
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Lanatoside C 纯度/质量文件 产品仅供科研

货号:A147174 标准纯度: {[allProObj[0].p_purity_real_show]}
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ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

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PFK-015 ++

PFKFB3, IC50: 207 nM

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MRT68921 hydrochloride ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

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ROC-325 {[allProObj[0].p_purity_real_show]}
Autophinib +++

Autophagy, IC50: 40 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Lanatoside C 生物活性

描述 Lanatoside C, a cardiac glycoside, is utilized in the management of congestive heart failure and cardiac arrhythmias. It demonstrates an IC50 of 0.19 μM against dengue virus in HuH-7 cells and is capable of inhibiting all four serotypes of dengue virus, as well as flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus, and human enterovirus 71[1].[2].
体外研究

Lanatoside C shows a dose-dependent reduction in both dengue viral RNA and protein synthesis with increased concentrations. Studies on the timing of addition reveal that Lanatoside C blocks the early stages of the dengue virus replication cycle. Additionally, it effectively inhibits all four dengue virus serotypes, flavivirus Kunjin, alphavirus Chikungunya, and Sindbis virus, along with human enterovirus 71, displaying a broad-spectrum antiviral activity against various positive-sense RNA viruses[2].

Lanatoside C 参考文献

[1]Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891(15)00226-4.

[2]Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99.

Lanatoside C 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.02mL

0.20mL

0.10mL

5.08mL

1.02mL

0.51mL

10.15mL

2.03mL

1.02mL

Lanatoside C 技术信息

CAS号17575-22-3
分子式C49H76O20
分子量 985.116
别名 毛花苷C
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(50.76 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

无水乙醇: 2 mg/mL(2.03 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

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