产品说明书
KH7
 |
同义名 : | KH 7 free |
| CAS号 : | 330676-02-3 | |
| 货号 : | A957502 | |
| 分子式 : | C17H15BrN4O2S | |
| 纯度 : | 99%+ | |
| 分子量 : | 419.296 | |
| MDL号 : | MFCD01230899 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(596.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Soluble adenylate cyclase (sAC) is a non-plasma membrane bound form of adenylate cyclase (AC) that produces the second messenger adenosine 3’,5’-cyclic AMP (cAMP) from ATP. It has been suggested to be involved in various cellular and physiological processes. KH 7, working as a classical uncoupler, is a sAC-specific inhibitor with an IC50 of 2.7 μM. KH 7 at 25 μM inhibited ATP production by reducing respiration at lower concentrations and by perturbing membrane potential at higher concentrations in isolated mouse liver mitochondria[2]. Application of the KH 7 showed almost complete inhibition of ATP-induced [Ca2+]i elevation in pretreated EA.hy926 cells indicating it reduces intracellular Ca2+ response[3]. In vivo, KH 7 (1.25 mM dissolved in 4 mL/kg DMSO) treatment caused an increased IOP (intraocular pressure) in avertin- and KXA(ketamine/xylazine/acepromazine)-anesthetized C57BL/6J mice compared with DMSO controls. In mice, KH 7 (5 μM) decreased outflow facility by 85.1% in nonanesthetized, enucleated eyes[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00035490 | Arrhythmia | Phase 3 | Completed | - | - |
| NCT03127059 | Dysfunctional Breathing in Ast... 展开 >>hma 收起 << | Not Applicable | Recruiting | November 2020 | Denmark ... 展开 >> Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Silkeborg, Central Denmark Region, Denmark, 8600 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Bispebjerg, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Allergi og Lungeklinikken Helsingør Recruiting Helsingør, Danish Capital Region, Denmark, 3000 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Hvidovre, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Aalborg, Region North, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Naestved, Region Zealand, Denmark Contact: Karen H Andreasson, PT MSc +45 24 25 49 26 khad@regionsjaelland.dk Contact: Uffe Bødtger, MD PhD +45 56 51 45 92 ubt@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Roskilde, Region Zealand, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk 收起 << |
| NCT03616912 | Systemic Lupus Erythematosus | Phase 3 | Recruiting | February 16, 2021 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.38mL 0.48mL 0.24mL |
11.92mL 2.38mL 1.19mL |
23.85mL 4.77mL 2.38mL |
| 参考文献 |
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