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产品名称 | MAO ↓ ↑ | MAO-A ↓ ↑ | MAO-B ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sennoside A |
++
MAO, IC50: 17 μM |
98%+ | |||||||||||||||||
Glycyrrhizic acid |
++++
MAO, IC50: 0.16 μM |
80% HPLC | |||||||||||||||||
Rasagiline |
++++
MAO-A, IC50: 412 nM |
++++
MAO-B, IC50: 4.43 nM |
99+% | ||||||||||||||||
Isatin |
++
MAO, IC50: 15 μM |
+
MAO-A, IC50: 58 μM |
++
MAO-B, IC50: 14 μM |
98% | |||||||||||||||
Paeonol |
+
MAO-A, IC50: 54.6 μM |
+
MAO-B, IC50: 42.5 μM |
98% | ||||||||||||||||
Tranylcypromine hydrochloride |
+++
MAO-A, IC50: 11.5 μM |
+++
MAO-B, IC50: 7 μM |
97% | ||||||||||||||||
Moclobemide |
+++
MAO-A (5-HT), IC50: 6.1 μM |
99%+ | |||||||||||||||||
Pargyline HCl |
++
MAO-A, Ki: 13 μM |
+++
MAO-B, Ki: 0.5 μM |
99%+ | ||||||||||||||||
Safinamide |
++++
MAO-B, IC50: 98 nM |
98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Iproniazid phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid phosphate has antidepressive activity[3]. Isaxonine phosphate induce acute hepatitis which in most cases is reversible after withdrawal of the drug[4]. This amount of octopamine was not significantly increased by either the monoamine oxidase inhibitor iproniazid phosphate (0.1 mM) or the uptake inhibitor desipramine (10 mM) alone, but was by both together. Nominally calcium-free saline containing 20 mM Mg++ significantly decreased octopamine release[5]. Iproniazid phosphate (0.36mM) increased the concentrations of the same acids in osmotically ruptured synaptosomes[6]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.61mL 0.72mL 0.36mL |
18.04mL 3.61mL 1.80mL |
36.07mL 7.21mL 3.61mL |
CAS号 | 305-33-9 |
分子式 | C9H16N3O5P |
分子量 | 277.214 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 |
DMSO: 105 mg/mL(378.77 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(180.37 mM) |
动物实验配方 |