产品说明书

Honokiol

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Chemical Structure| 35354-74-6 同义名 : NSC 293100
CAS号 : 35354-74-6
货号 : A146214
分子式 : C18H18O2
纯度 : 98%
分子量 : 266.334
MDL号 : MFCD00016674
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(187.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

2% DMSO+40% PEG 300+2% Tween 80+water 2 mg/mL

生物活性
靶点

  • Akt

  • MEK
描述 Honokiol is a phenylpropanoid molecule, a biaryl-type lignan, present in the genus Magnolia. Neonatal rats, when injected with honokiol (10 mg/kg), acute pain response was subdued. And the application of 25 mg/kg honokiol to guinea pig models lowered the testosterone level[3]. In addition,honokiol was able to prevent doxorubicin (Dox)-induced senescence of H9c2 cardiomyocytes [4]. Honokiol (10 mg/kg, orally) effectively reversed the hepatotoxicity indices elevations and abnormal histopathological changes induced by Concanavalin A (Con A)[5].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 cells Function assay Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM 20695472
HEK293 cells Function assay 24-48 h Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay 24959987
Hep-G2 cells Cytotoxicity assay Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM 15582432
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.55mL

7.51mL

3.75mL
参考文献

[1]Ishitsuka K, Hideshima T, et al. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood. 2005 Sep 1;106(5):1794-800.

[2]Bai X, Cerimele F, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003 Sep 12;278(37):35501-7.

[3]Wu XY, Zhang CX, Deng LC, Xiao J, Yuan X, Zhang B, Hou ZB, Sheng ZH, Sun L, Jiang QC, Zhao W. Overexpressed D2 Dopamine Receptor Inhibits Non-Small Cell Lung Cancer Progression through Inhibiting NF-κB Signaling Pathway. Cell Physiol Biochem. 2018;48(6):2258-2272. doi: 10.1159/000492644. Epub 2018 Aug 16. PMID: 30114693.

[4]Huang PP, Fu J, Liu LH, Wu KF, Liu HX, Qi BM, Liu Y, Qi BL. Honokiol antagonizes doxorubicin‑induced cardiomyocyte senescence by inhibiting TXNIP‑mediated NLRP3 inflammasome activation. Int J Mol Med. 2020 Jan;45(1):186-194. doi: 10.3892/ijmm.2019.4393. Epub 2019 Nov 1. PMID: 31746354; PMCID: PMC6889937.

[5]Elfeky MG, Mantawy EM, Gad AM, Fawzy HM, El-Demerdash E. Mechanistic aspects of antifibrotic effects of honokiol in Con A-induced liver fibrosis in rats: Emphasis on TGF-β/SMAD/MAPK signaling pathways. Life Sci. 2020 Jan 1;240:117096. doi: 10.1016/j.lfs.2019.117096. Epub 2019 Nov 21. PMID: 31760097.