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Harmine

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Chemical Structure| 442-51-3 同义名 : 哈尔碱 ;Telepathine
CAS号 : 442-51-3
货号 : A350584
分子式 : C13H12N2O
纯度 : 98%
分子量 : 212.247
MDL号 : MFCD00004958
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(141.34 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • DYRK1

    DYRK1B, IC50:166 nM

    DYRK1A, IC50:33 nM

  • DYRK2

    DYRK2, IC50:1.9 μM
描述 Harmine is a beta-carboline alkaloid found in medicinal plant Peganum Harmala, which has served as a folk anticancer medicine. Harmine decreased the survival of HepG2 Cells and the cell survival rates were decreased with increasing the compounds concentrations (from 0 to 10 μM). In vivo,the mice receiving 100 mg/kg harmine exhibited neurotoxic behaviors immediately[3].In addition, harmine administration was associated with neuroprotective effects and also improved memory/learning in several animal models[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02914769 Major Depression Phase 1 Phase 2 Completed - Brazil ... 展开 >> Draulio B de Araujo Natal, Rio Grande do Norte, Brazil, 59012-300 收起 <<
NCT02379767 - Unknown February 2018 Austria ... 展开 >> Department of Psychiatry and Psychotherapy Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, Assoc. Prof. PD MD    +43-1-40400-35760    rupert.lanzenberger@meduniwien.ac.at 收起 <<
NCT02715232 Gender Dysphoria Phase 4 Recruiting December 2020 Austria ... 展开 >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, A/Prof.    +43 40400 ext 3825    rupert.lanzenberger@meduniwien.ac.at    Principal Investigator: Rupert Lanzenberger, A/Prof. MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.11mL

9.42mL

4.71mL
参考文献

[1]Chen D, Su A, et al. Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral Res. 2015 Nov;123:27-38.

[2]Zhang H, Sun K, et al. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine. 2014 Feb 15;21(3):348-55.

[3]Li S, Wang A, Gu F, Wang Z, Tian C, Qian Z, Tang L, Gu Y. Novel harmine derivatives for tumor targeted therapy. Oncotarget. 2015 Apr 20;6(11):8988-9001. doi: 10.18632/oncotarget.3276. PMID: 25940702; PMCID: PMC4496197.

[4]Dos Santos RG, Hallak JE. Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies. J Psychoactive Drugs. 2017 Jan-Mar;49(1):1-10. doi: 10.1080/02791072.2016.1260189. Epub 2016 Dec 5. PMID: 27918874.