Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities[3]. GA-A (6.25-100 μM) significantly inhibited cyst growth in MDCK cyst model and embryonic kidney cyst model in vitro, and the inhibitory effect was reversible. In kidney-specific Pkd1 knockout (kPKD) mice displaying severe cystic kidney disease, administration of GA-A (50 mg· kg-1 ·d-1, sc) significantly attenuated renal cyst development[4]. Pretreatment with GA A (10 μM) significantly attenuated SNP(sodium nitroprusside)-induced cytotoxicity and NO (nitric oxide) increase in SH-SY5Y cells, but not in PC12 cells. Furthermore, pretreatment with GA A caused significantly higher adrenaline content in SH-SY5Y cells than in PC12 cells[5]. GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway[6].
Ganoderic acid A 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
Bel7402 cells
Cytotoxicity assay
Cytotoxicity against human Bel7402 cells, IC50=7.25 μM
23092389
HepG2 cells
Function assay
48 h
Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=38.7 μM
24974349
P388 cells
Cytotoxicity assay
Cytotoxicity against mouse P388 cells, IC50=7.25 μM
23092389
SGC7901 cells
Cytotoxicity assay
Cytotoxicity against human SGC7901 cells, IC50=7.25 μM
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