There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
GRI977143, a targeted LPA2 receptor agonist, has an EC50 of 3.3 μM. At a concentration of 10 μM over 24-72 hours, GRI977143 effectively diminishes the activation of caspases 3, 7, 8, and 9, and prevents cleavage of PARP1 and DNA fragmentation in various models of apoptosis. It also acts as a potent enhancer of extracellular signal-regulated kinase 1/2 activation and facilitates the formation of a large signaling complex that includes LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6. At 10 μM, GRI977143 does not significantly increase vector cell proliferation until 72 hours. In MEF cells subjected to doxorubicin-induced apoptotic signaling, either vector-transduced or LPA2-transduced, a 10 μM concentration of GRI977143 reduces the activation of caspase 3 and 7 by 51 ± 3% and is nearly as effective as 3 μM LPA or OTP in protecting against doxorubicin-induced apoptosis by inhibiting caspases 3, 7, 8, and 9 and lessening DNA fragmentation[1].
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HazMat Fee +
