Folinic acid calcium
产品说明书
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同义名 : | 亚叶酸钙 ;Leucovorin calcium;Calcium folinate;5-Formyltetrahydrofolate;NSC 3590;DL-Folinate;DL-Folinic Acid (calcium salt);Wellcovorin;Folinic acid calcium salt |
| CAS号 : | 1492-18-8 | |
| 货号 : | A161719 | |
| 分子式 : | C20H21CaN7O7 | |
| 纯度 : | 95% | |
| 分子量 : | 511.501 | |
| MDL号 : | MFCD08704249 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 50 mg/mL(97.75 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Calcium Folinate (CF) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX (methotrexate) in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX[3]. Uracil and tegafur (UFT) plus calcium folinate are the components of the oral agent known as Orzel, which offers activity comparable to intravenously administered 5-fluorouracil (5-FU) combined with calcium folinate[4]. UFT (uracil and tegafur) plus oral calcium folinate (Orzel) offers significant antitumor activity and an acceptable toxicity profile makes this a logical formulation for the adjuvant treatment of colon cancer[5]. Furthermore, tegafur/uracil + calcium folinate is well tolerated, with dose-limiting toxicity manifesting as diarrhoea. Compared with intravenous fluorouracil plus folinic acid (leucovorin) regimens, tegafur/uracil + calcium folinate has similar efficacy with less toxicity and is more convenient because it is an oral regimen[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00591045 | Stomach Neoplasms ... 展开 >> Gastric Cancer 收起 << | Phase 2 | Unknown | December 2012 | China, Beijing ... 展开 >> Peking University School of Oncology Not yet recruiting Beijing, Beijing, China, 100036 Contact: Jiafu Ji, M.D. 86-10-88196048 jiafuj@hotmail.com Principal Investigator: Jiafu Ji, M.D. 收起 << |
| NCT02573220 | Stage IVA Colorectal Cancer ... 展开 >> Stage IVB Colorectal Cancer 收起 << | Phase 1 | Withdrawn(Study terminated by ... 展开 >>PI due to inability to accrue.) 收起 << | - | Italy ... 展开 >> Centro di Riferimento Oncologico Aviano, Italy, 33081 收起 << |
| NCT00677287 | Colorectal Cancer ... 展开 >> Colon Cancer Rectal Cancer 收起 << | Phase 1 Phase 2 | Terminated(Lack of financial s... 展开 >>upport) 收起 << | - | Japan ... 展开 >> The Institute of Medical Science, the University of Tokyo Minato-ku, Tokyo, Japan, 108-8639 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.96mL 0.39mL 0.20mL |
9.78mL 1.96mL 0.98mL |
19.55mL 3.91mL 1.96mL |
| 参考文献 |
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