Ferulic Acid

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Chemical Structure| 1135-24-6 同义名 : 3-甲氧基-4-羟基苯基丙烯酸 ;Coniferic acid;4-hydroxy-3-Methoxycinnamic Acid;Ferulic Acid, Methyl ferulate, trans-Ferulic acid, Coniferic acid, NSC 2821, NSC2821, NSC-2821;NSC 674320;NSC 51986;NSC 2821;Fumalic Acid
CAS号 : 1135-24-6
货号 : A137025
分子式 : C10H10O4
纯度 : 98%
分子量 : 194.184
MDL号 : MFCD00004400
存储条件：

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(540.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • FGFR2

    FGFR2, IC50:12.5 μM

  • FGFR1

    FGFR1, IC50:3.78 μM
描述 Ferulic Acid, a kind of phenolic compound isolated from Tetragonia tetragonioides, has many biological activities. In vitro studies, ferulic acid has whitening effect on the B16F10 mouse melanoma cell line and anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line, while shows no cytotoxicity at concentrations up to 20 μM[1]. Besides this, it was found that ferulic acid could effectively inhibit the epidermal growth factor receptor (EGFR) in human breast cancer cells, through down-regulating the Tyr 1068 autophosphorylation[2]. In vivo studies, ferulic acid has the ability of ameliorating the diabetes-induced cognition lesions in rat via the regulation of protein tyrosine phosphatase 1B (PTP1B) and insulin signaling pathway[3]. In addition, ferulic acid could contribute to the reversal of inflammatory response induced by chronic unpredictable mild stress (CUMS) in mice[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03092076 Healthy Phase 1 Completed - -
NCT01982734 Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 << Early Phase 1 Completed - Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT02944084 Safety After Oral Intake ... 展开 >> Pharmacokinetics After Oral Intake 收起 << Early Phase 1 Completed - Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.52mL

25.75mL

5.15mL

2.57mL

51.50mL

10.30mL

5.15mL
参考文献

[1]Park HJ, Cho JH, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells. J Nat Med. 2018;72(1):127-135.

[2]Sudhagar S, Sathya S, et al. Inhibition of epidermal growth factor receptor by ferulic acid and 4-vinylguaiacol in human breast cancer cells. Biotechnol Lett. 2018;40(2):257-262.

[3]Wang H, Sun X, et al. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiol Behav. 2017.

[4]Liu YM, Shen JD, et al. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. Int Immunopharmacol. 2017.