货号:A876758 同义名: Redupresin;L-643786
Ethoxzolamide is an inhibitor of carbonic anhydrase with (Ki = 1 nM).
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产品名称 | Carbonic Anhydrase ↓ ↑ | Carbonic Anhydrase I ↓ ↑ | Carbonic Anhydrase II ↓ ↑ | Carbonic Anhydrase IV ↓ ↑ | Carbonic Anhydrase IX ↓ ↑ | Carbonic Anhydrase XII ↓ ↑ | 其他靶点 | 纯度 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Topiramate | ✔ | Calcium Channel | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Dichlorphenamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Mafenide Acetate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Benzenesulphonamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dorzolamide HCl |
+
Carbonic anhydrase I, Ki: 6000 nM |
++++
Carbonic anhydrase II, Ki: 1.9 nM |
+++
Carbonic anhydrase IV, Ki: 31 nM |
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Methazolamide |
++
hCAI, Ki: 50 nM |
+++
hCAII, Ki: 14 nM |
++
bCAIV, Ki: 36 nM |
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Tioxolone |
+
CAI, Ki: 91 nM |
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U-104 |
++
CAIX, Ki: 45.1 nM |
++++
CAXII, Ki: 4.5 nM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Ethoxzolamide (ETZ) leads to more than 90% inhibition of GFP reporter fluorescence in macrophages infected with M. tuberculosis. Additionally, in a 9-day macrophage survival assay, ETZ significantly curtails the intracellular growth of M. tuberculosis[2]. |
体内研究 | Lipid-soluble ethoxzolamide is metabolized in vivo into a water-soluble metabolite, maintaining high activity against its target enzyme. At the minimal effective dose of 4 mg/kg intravenously administered at 45 minutes, the intraocular pressure (IOP) reduction is 4.2 mmHg, with a concentration of 2.5 pmol/kg in the anterior uvea, and near-complete enzyme inhibition (fractional inhibition, i = 0.9995). The effect decreases quickly, largely due to the drug's very short half-life in plasma, which results in a rapid decline of free drug availability in the anterior uvea and other tissues[1]. In mouse lungs, ETZ treatment substantially downregulates GFP reporter fluorescence, achieving a 3-fold reduction in GFP signal compared to mock-treated controls. There is also a notable decrease in bacterial survival in the lungs of mice treated with ETZ compared to those receiving mock treatment[2]. |
体外研究 | Ethoxzolamide (ETZ) leads to more than 90% inhibition of GFP reporter fluorescence in macrophages infected with M. tuberculosis. Additionally, in a 9-day macrophage survival assay, ETZ significantly curtails the intracellular growth of M. tuberculosis[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.87mL 0.77mL 0.39mL |
19.36mL 3.87mL 1.94mL |
38.71mL 7.74mL 3.87mL |
CAS号 | 452-35-7 |
分子式 | C9H10N2O3S2 |
分子量 | 258.317 |
别名 | Redupresin;L-643786;6-Ethoxyzolamide;Ethoxzolamide, Ethoxyzolamide, Ethoxazolamide, Cardrase, Ethamide;PNU-4191 |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(406.48 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |