产品说明书

	同义名 :	-
	CAS号 :	87304-15-2
	货号 :	A472273
	分子式 :	C21H32N2O6
	纯度 :	97%
	分子量 :	408.489
	MDL号 :	MFCD31631159
	存储条件：	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].Ubiquitin E3 ligase-mediated protein degradation promotes proteasomal degradation of key positive regulators of osteoblast functions[2]. E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.45mL 0.49mL 0.24mL	12.24mL 2.45mL 1.22mL	24.48mL 4.90mL 2.45mL

参考文献

[1]Bricelj A, Steinebach C, Kuchta R, Gütschow M, Sosič I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points. Front Chem. 2021 Jul 5;9:707317 [2]Shu L, Zhang H, Boyce BF, Xing L. Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration. J Bone Miner Res. 2013 Sep;28(9):1925-35 [3]Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL, Liu H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 2020 Mar 4;10(9):4150-4167