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Derrone {[allProObj[0].p_purity_real_show]}

货号:A423162

Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.

Derrone 化学结构 CAS号:76166-59-1
Derrone 化学结构
CAS号:76166-59-1
Derrone 3D分子结构
CAS号:76166-59-1
Derrone 化学结构 CAS号:76166-59-1
Derrone 3D分子结构 CAS号:76166-59-1
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Derrone 纯度/质量文件 产品仅供科研

货号:A423162 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Aurora A Aurora B Aurora C 其他靶点 纯度
BI-847325 ++

Aurora A (Human), IC50: 25 nM

++++

Aurora B (Xenopus laevis), IC50: 3 nM

++

Aurora C (Human), IC50: 15 nM

99%+
CCT 137690 ++

Aurora A, IC50: 15 nM

++

Aurora B, IC50: 25 nM

++

Aurora C, IC50: 19 nM

99%+
MK-5108 ++++

Aurora A, IC50: 0.064 nM

99%+
KW-2449 +

Aurora A, IC50: 48 nM

FLT3 99%+
Tozasertib ++++

Aurora A, Ki app: 0.6 nM

++

Aurora B, Ki app: 18 nM

+++

Aurora C, Ki app: 4.6 nM

Bcr-Abl,FLT3 99%+
AT9283 ++++

Aurora A, IC50: ~3.0 nM

++++

Aurora B, IC50: ~3.0 nM

99%+
MLN8054 +++

Aurora A, IC50: 4 nM

+

Aurora B, IC50: 172 nM

99%+
ZM-447439 +

Aurora A, IC50: 110 nM

+

Aurora B, IC50: 130 nM

Src 99%+
TCS7010 ++++

Aurora A, IC50: 3.4 nM

99%+
TAK-901 ++

Aurora A-TPX2, IC50: 21 nM

++

Aurora B-INCENP, IC50: 15 nM

99%+
Danusertib +++

Aurora A, IC50: 13 nM

+

Aurora B, IC50: 79 nM

+

Aurora C, IC50: 61 nM

RET 99%+
MK-8745 ++++

Aurora A, IC50: 0.6 nM

99+%
PHA-680632 ++

Aurora A, IC50: 27 nM

+

Aurora B, IC50: 135 nM

+

Aurora C, IC50: 120 nM

FLT3 99%+
AMG 900 +++

Aurora A, IC50: 5 nM

+++

Aurora B, IC50: 4 nM

++++

Aurora C, IC50: 1 nM

99%+
Alisertib ++++

Aurora A, IC50: 1.2 nM

99%+
ENMD-2076 +++

Aurora A, IC50: 14 nM

+

Aurora B, IC50: 350 nM

RET,FLT3 98%
JNJ-7706621 +++

Aurora A, IC50: 11 nM

++

Aurora B, IC50: 15 nM

99%+
CYC-116 +++

Aurora A, Ki: 8 nM

+++

Aurora B, Ki: 9 nM

FLT3 99%+
Reversine +++

Aurora A, IC50: 12 nM

+++

Aurora B, IC50: 13 nM

++

Aurora C, IC50: 20 nM

98%
CCT129202 ++

Aurora A, IC50: 42 nM

+

Aurora B, IC50: 198 nM

+

Aurora C, IC50: 227 nM

98%
SNS-314 mesylate +++

Aurora A, IC50: 9 nM

++

Aurora B, IC50: 31 nM

++++

Aurora C, IC50: 3 nM

99%+
Barasertib-HQPA ++++

Aurora B, IC50: 0.37 nM

99%+
Hesperadin +

Aurora B (human), IC50: 250 nM

98%
GSK-1070916 ++++

Aurora B-INCENP, IC50: 3.5 nM

+++

Aurora C-INCENP, IC50: 6.5 nM

Tie-2,SIK 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 PERK 其他靶点 纯度
ISRIB ++

PERK, IC50: 5 nM

98%
GSK2656157 +++

PERK, IC50: 0.9 nM

99%+
GSK2606414 ++++

EIF2AK3 (PERK), IC50: 0.4 nM

99%+
Salubrinal 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Derrone 生物活性

描述 Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.

Derrone 参考文献

[1]Hoang NT, Phuong TT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39(6):935-45.

[2]Edziri H, Mastouri M, et al. Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowers. Molecules. 2012 Jun 13;17(6):7284-93.

Derrone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.87mL

2.97mL

1.49mL

29.73mL

5.95mL

2.97mL

Derrone 技术信息

CAS号76166-59-1
分子式C20H16O5
分子量 336.34
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度
动物实验配方
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